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    BAK1 BCL2 antagonist/killer 1 [ Bos taurus (cattle) ]

    Gene ID: 514090, updated on 5-Mar-2024

    Summary

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    Official Symbol
    BAK1provided by VGNC
    Official Full Name
    BCL2 antagonist/killer 1provided by VGNC
    Primary source
    VGNC:VGNC:26416
    See related
    BGD:BT19932
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BAK1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (7712944..7720170, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene uncharacterized LOC112443859 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene uncharacterized LOC100847319 Neighboring gene gametogenetin binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucocorticoid modulation of Bcl-2 family members A1 and Bak during delayed spontaneous apoptosis of bovine blood neutrophils. Madsen-Bouterse SA, et al. Endocrinology, 2006 Aug. PMID 16675521
    2. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulation of A1 and Bak contribute to mitochondrial membrane stability, reduced caspase-9 activity, and delayed apoptosis in bovine neutrophils exposed to glucocorticoids
      Title: Glucocorticoid modulation of Bcl-2 family members A1 and Bak during delayed spontaneous apoptosis of bovine blood neutrophils.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bcl-2 homologous antagonist/killer
    Names
    Bcl-2-like 7
    apoptosis regulator BAK

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077918.1 → NP_001071386.1  bcl-2 homologous antagonist/killer

      See identical proteins and their annotated locations for NP_001071386.1

      Status: PROVISIONAL

      Source sequence(s)
      AB238939
      UniProtKB/TrEMBL
      Q05KI7
      Conserved Domains (1) summary
      cd06845
      Location:30 → 183
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7712944..7720170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880315.1 → XP_059736298.1  bcl-2 homologous antagonist/killer isoform X1

      UniProtKB/TrEMBL
      Q05KI7

    2. XM_005223241.5 → XP_005223298.1  bcl-2 homologous antagonist/killer isoform X1

      See identical proteins and their annotated locations for XP_005223298.1

      UniProtKB/TrEMBL
      Q05KI7
      Conserved Domains (1) summary
      cd06845
      Location:30 → 183
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    3. XM_015459725.3 → XP_015315211.1  bcl-2 homologous antagonist/killer isoform X1

      UniProtKB/TrEMBL
      Q05KI7
      Conserved Domains (1) summary
      cd06845
      Location:30 → 183
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    Nucleotide Protein Strain
    Heading Accession and Version

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