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    BCL2L1 BCL2 like 1 [ Bos taurus (cattle) ]

    Gene ID: 282152, updated on 5-Mar-2024

    Summary

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    Official Symbol
    BCL2L1provided by VGNC
    Official Full Name
    BCL2 like 1provided by VGNC
    Primary source
    VGNC:VGNC:26446
    See related
    BGD:BT11631; Ensembl:ENSBTAG00000006526
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BCLX; Bcl-xL
    Orthologs
    human mouse all
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    Genomic context

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    See BCL2L1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (61220110..61271376, complement)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 1 Neighboring gene cytochrome c oxidase subunit 4I2 Neighboring gene uncharacterized LOC107133075 Neighboring gene TPX2 microtubule nucleation factor Neighboring gene uncharacterized LOC132346946 Neighboring gene myosin light chain kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the bovine BCL2L1 gene and related pseudogenes. Amills M, et al. Anim Genet, 2003 Dec. PMID 14687078
    2. Regulation of Bcl-xL expression in lung vascular smooth muscle. Suzuki YJ, et al. Am J Respir Cell Mol Biol, 2007 Jun. PMID 17272823, Free PMC Article
    3. Assignment of the bovine B-cell CLL/lymphoma 2 gene (BCL2) to BTA24q27 and the bovine BCL2-like 1 gene (BCL2L1) to BTA13q22 by in situ hybridization. Goldammer T, et al. Cytogenet Genome Res, 2006. PMID 16484795
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Bcl-x(L) expression is increased in the pulmonary artery undergoing chronic pulmonary vascular remodeling.
      Title: Regulation of Bcl-xL expression in lung vascular smooth muscle.
    2. amplification and characterization of partial regions of exons 2 and 3 of the bovine BCL2L1 gene
      Title: Characterization of the bovine BCL2L1 gene and related pseudogenes.
    3. chromosome mapping by in situ hybridization.
      Title: Assignment of the bovine B-cell CLL/lymphoma 2 gene (BCL2) to BTA24q27 and the bovine BCL2-like 1 gene (BCL2L1) to BTA13q22 by in situ hybridization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bcl-2-like protein 1
    Names
    BCL2-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077486.2 → NP_001070954.1  bcl-2-like protein 1

      See identical proteins and their annotated locations for NP_001070954.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133281
      UniProtKB/TrEMBL
      Q05KJ0, Q462R5
      Conserved Domains (3) summary
      smart00265
      Location:1 → 27
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:65 → 194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 233
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      61220110..61271376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005214498.5 → XP_005214555.1  bcl-2-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005214555.1

      UniProtKB/TrEMBL
      Q05KJ0, Q462R5
      Conserved Domains (3) summary
      smart00265
      Location:1 → 27
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:65 → 194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 233
      bcl-2; apoptosis regulator

    2. XM_005214497.3 → XP_005214554.1  bcl-2-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005214554.1

      UniProtKB/TrEMBL
      Q05KJ0, Q462R5
      Related
      ENSBTAP00000070613.1, ENSBTAT00000076163.1
      Conserved Domains (3) summary
      smart00265
      Location:1 → 27
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:65 → 194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 233
      bcl-2; apoptosis regulator

    3. XM_010811365.3 → XP_010809667.1  bcl-2-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_010809667.1

      UniProtKB/TrEMBL
      Q05KJ0, Q462R5
      Conserved Domains (3) summary
      smart00265
      Location:1 → 27
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:65 → 194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 233
      bcl-2; apoptosis regulator
    Nucleotide Protein Strain
    Heading Accession and Version

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