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    MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Bos taurus (cattle) ]

    Gene ID: 520058, updated on 6-Jun-2024

    Summary

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    Official Symbol
    MAP4K2provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:31205
    See related
    BGD:BT26942; Ensembl:ENSBTAG00000001037
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MAP4K2 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (43022838..43040967, complement)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene splicing factor 1 Neighboring gene menin 1 Neighboring gene transfer RNA glutamic acid (anticodon CUC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables MAP kinase kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 2
    NP_001193204.1
    XP_024842925.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206275.1 → NP_001193204.1  mitogen-activated protein kinase kinase kinase kinase 2

      See identical proteins and their annotated locations for NP_001193204.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000029
      UniProtKB/TrEMBL
      E1B902
      Related
      ENSBTAP00000001378.6, ENSBTAT00000001378.6
      Conserved Domains (3) summary
      smart00036
      Location:488 → 800
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:16 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16 → 272
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43022838..43040967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024987157.2 → XP_024842925.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T7W6, E1B902
      Related
      ENSBTAP00000092879.1, ENSBTAT00000124257.1
      Conserved Domains (2) summary
      smart00036
      Location:488 → 789
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:16 → 272
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version

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