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    SYNGAP1 synaptic Ras GTPase activating protein 1 [ Bos taurus (cattle) ]

    Gene ID: 790307, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SYNGAP1provided by VGNC
    Official Full Name
    synaptic Ras GTPase activating protein 1provided by VGNC
    Primary source
    VGNC:VGNC:35523
    See related
    BGD:BT22023; Ensembl:ENSBTAG00000020975
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SYNGAP1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (7594069..7625618)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 1 Neighboring gene cutA divalent cation tolerance homolog Neighboring gene uncharacterized LOC112443859 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene BCL2 antagonist/killer 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras/Rap GTPase-activating protein SynGAP
    Names
    synaptic Ras GTPase activating protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205466.1 → NP_001192395.1  ras/Rap GTPase-activating protein SynGAP

      See identical proteins and their annotated locations for NP_001192395.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000023
      UniProtKB/TrEMBL
      F1MBI8
      Related
      ENSBTAP00000027936.5, ENSBTAT00000027936.7
      Conserved Domains (7) summary
      cd04013
      Location:252 → 415
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:406 → 729
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:402 → 721
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam00169
      Location:188 → 251
      PH; PH domain
      pfam08912
      Location:1199 → 1258
      Rho_Binding; Rho Binding
      pfam12004
      Location:719 → 1313
      DUF3498; Domain of unknown function (DUF3498)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7594069..7625618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880467.1 → XP_059736450.1  ras/Rap GTPase-activating protein SynGAP isoform X2

    2. XM_059880468.1 → XP_059736451.1  ras/Rap GTPase-activating protein SynGAP isoform X2

    3. XM_059880466.1 → XP_059736449.1  ras/Rap GTPase-activating protein SynGAP isoform X1

    4. XM_059880470.1 → XP_059736453.1  ras/Rap GTPase-activating protein SynGAP isoform X4

    5. XM_005223277.4 → XP_005223334.1  ras/Rap GTPase-activating protein SynGAP isoform X7

      See identical proteins and their annotated locations for XP_005223334.1

      Related
      ENSBTAP00000080218.1, ENSBTAT00000128961.1
      Conserved Domains (4) summary
      cd04013
      Location:252 → 415
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:406 → 729
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:719 → 1267
      DUF3498; Domain of unknown function (DUF3498)

    6. XM_059880469.1 → XP_059736452.1  ras/Rap GTPase-activating protein SynGAP isoform X3

    7. XM_010818073.4 → XP_010816375.1  ras/Rap GTPase-activating protein SynGAP isoform X7

      See identical proteins and their annotated locations for XP_010816375.1

      Conserved Domains (4) summary
      cd04013
      Location:252 → 415
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:406 → 729
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:719 → 1267
      DUF3498; Domain of unknown function (DUF3498)

    8. XM_059880472.1 → XP_059736455.1  ras/Rap GTPase-activating protein SynGAP isoform X6

      Related
      ENSBTAP00000101979.1, ENSBTAT00000130036.1

    9. XM_059880471.1 → XP_059736454.1  ras/Rap GTPase-activating protein SynGAP isoform X5

    10. XM_059880475.1 → XP_059736458.1  ras/Rap GTPase-activating protein SynGAP isoform X10

    11. XM_059880474.1 → XP_059736457.1  ras/Rap GTPase-activating protein SynGAP isoform X9

      Related
      ENSBTAP00000079652.1, ENSBTAT00000128118.1

    12. XM_059880473.1 → XP_059736456.1  ras/Rap GTPase-activating protein SynGAP isoform X8

      Related
      ENSBTAP00000088017.1, ENSBTAT00000123754.1

    13. XM_059880476.1 → XP_059736459.1  ras/Rap GTPase-activating protein SynGAP isoform X10

    RNA

    1. XR_009492485.1 RNA Sequence

    2. XR_009492484.1 RNA Sequence

    3. XR_814706.3 RNA Sequence

    4. XR_009492486.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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