SERPINB1 serpin family B member 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: SERPINB1provided by VGNC
Official Full Name: serpin family B member 1provided by VGNC
Primary source: VGNC:VGNC:34470
See related: Ensembl:ENSBTAG00000011975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: LEI
Orthologs: human all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (50820715..50829831)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the function of LEI during wound healing is related to its activity as a protease inhibitor and/or to its anti-apoptotic activity.
Title: Increase in the expression of leukocyte elastase inhibitor during wound healing in corneal endothelial cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leukocyte elastase inhibitor

Names: leukocyte elastase inhibitor pseudogene; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1; serpin B1; serpin peptidase inhibitor, clade B (ovalbumin), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206610.1 → NP_001193539.1 leukocyte elastase inhibitor

See identical proteins and their annotated locations for NP_001193539.1

Status: VALIDATED

Source sequence(s)

BT025443, DY039389

UniProtKB/Swiss-Prot

Q1JPB0

Conserved Domains (1) summary

cl00137
Location:4 → 377

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

Range

50820715..50829831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024983469.2 → XP_024839237.1 leukocyte elastase inhibitor isoform X1

UniProtKB/TrEMBL

A0A3Q1LN63

Related

ENSBTAP00000058218.1, ENSBTAT00000068456.2

Conserved Domains (1) summary

cl00137
Location:37 → 410

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
XM_024983470.2 → XP_024839238.1 leukocyte elastase inhibitor isoform X2

UniProtKB/Swiss-Prot

Q1JPB0

Related

ENSBTAP00000015889.5, ENSBTAT00000015889.6

Conserved Domains (1) summary

cl00137
Location:4 → 377

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...