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    HTR1A 5-hydroxytryptamine receptor 1A [ Bos taurus (cattle) ]

    Gene ID: 407137, updated on 5-Mar-2024

    Summary

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    Official Symbol
    HTR1Aprovided by VGNC
    Official Full Name
    5-hydroxytryptamine receptor 1Aprovided by VGNC
    Primary source
    VGNC:VGNC:29991
    See related
    BGD:BT12229; Ensembl:ENSBTAG00000040439
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    5HT1A; 5htr1a
    Orthologs
    human mouse all
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    Genomic context

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    See HTR1A in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (15586651..15589209)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 180 Neighboring gene microRNA mir-320a-2 Neighboring gene uncharacterized LOC112443030 Neighboring gene uncharacterized LOC101907219 Neighboring gene importin 11 Neighboring gene leucine rich repeat containing 70

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane cholesterol oxidation inhibits ligand binding function of hippocampal serotonin(1A) receptors. Pucadyil TJ, et al. Biochem Biophys Res Commun, 2005 Jun 3. PMID 15850776
    2. Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus. Chattopadhyay A, et al. Biochem Biophys Res Commun, 2005 Feb 25. PMID 15652500
    3. Calmodulin interacts with the third intracellular loop of the serotonin 5-hydroxytryptamine1A receptor at two distinct sites: putative role in receptor phosphorylation by protein kinase C. Turner JH, et al. J Biol Chem, 2004 Apr 23. PMID 14752100
    4. Quantitative mRNA analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR. Reist M, et al. J Recept Signal Transduct Res, 2003. PMID 14753293
    5. 5-HT(2) receptor-mediated phosphoinositide hydrolysis in bovine ciliary epithelium. Inoue-Matsuhisa E, et al. J Ocul Pharmacol Ther, 2003 Feb. PMID 12648304

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role of cholesterol in solubilization of G-protein-coupled serotonin 1A receptors
      Title: Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus.
    2. the 5-HT(1A) receptor contains high and moderate affinity CaM binding regions that may play important roles in receptor signaling and function
      Title: Calmodulin interacts with the third intracellular loop of the serotonin 5-hydroxytryptamine1A receptor at two distinct sites: putative role in receptor phosphorylation by protein kinase C.
    3. 5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium.
      Title: 5-HT(2) receptor-mediated phosphoinositide hydrolysis in bovine ciliary epithelium.
    4. analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
      Title: Quantitative mRNA analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR.
    5. ligand binding function of the 5-HT(1A) receptor is a cholesterol-dependent phenomenon that is not related to the ability of cholesterol to modulate membrane order
      Title: Membrane cholesterol oxidation inhibits ligand binding function of hippocampal serotonin(1A) receptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15586651..15589209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002696304.6 → XP_002696350.1  5-hydroxytryptamine receptor 1A

      See identical proteins and their annotated locations for XP_002696350.1

      UniProtKB/TrEMBL
      F6Q2H9
      Related
      ENSBTAP00000048502.2, ENSBTAT00000054712.3
      Conserved Domains (1) summary
      cd15330
      Location:37 → 411
      7tmA_5-HT1A_vertebrates; serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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