SFRP4 secreted frizzled related protein 4 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: SFRP4provided by VGNC
Official Full Name: secreted frizzled related protein 4provided by VGNC
Primary source: VGNC:VGNC:34522
See related: BGD:BT12875; Ensembl:ENSBTAG00000015366
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (49731830..49742113, complement)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Wnt antagonist SFRP4 and adipogenic gene expression following castration, contributes to increased intramuscular fat deposition in the longissimus dorsi muscle.
Title: Wnt/β-catenin signaling and adipogenic genes are associated with intramuscular fat content in the longissimus dorsi muscle of Korean cattle.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: secreted frizzled-related protein 4

Names: secreted frizzled-relatedprotein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001075764.1 → NP_001069232.1 secreted frizzled-related protein 4 precursor

See identical proteins and their annotated locations for NP_001069232.1

Status: PROVISIONAL

Source sequence(s)

BC118245

UniProtKB/TrEMBL

Q17QP5

Related

ENSBTAP00000020424.5, ENSBTAT00000020424.6

Conserved Domains (2) summary

cl02447
Location:20 → 146

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl02512
Location:188 → 296

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...