Wnt3a Wnt family member 3A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wnt3aprovided by RGD
Official Full Name: Wnt family member 3Aprovided by RGD
Primary source: RGD:1308057
See related: Ensembl:ENSRNOG00000003039 AllianceGenome:RGD:1308057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including co-receptor binding activity; signaling receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway involved in heart development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of macromolecule metabolic process. Predicted to be located in cell surface. Predicted to be part of Wnt-Frizzled-LRP5/6 complex. Predicted to be active in extracellular space and glutamatergic synapse. Biomarker of hypothyroidism. Orthologous to human WNT3A (Wnt family member 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 66.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44533734..44577919, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44034174..44078366, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45598898..45643151, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt-3a improves functional recovery after spinal cord injury by regulating the inflammatory and apoptotic response in rats via wnt/beta-catenin signaling pathway.
Title: Wnt-3a improves functional recovery after spinal cord injury by regulating the inflammatory and apoptotic response in rats via wnt/β-catenin signaling pathway.
Wnt3a promotes odonto/osteogenic differentiation in vitro and tertiary dentin formation in a rat model.
Title: Wnt3a promotes odonto/osteogenic differentiation in vitro and tertiary dentin formation in a rat model.
Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands.
Title: Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands.
Wnt3a upregulation is involved in TGFbeta1-induced cardiac hypertrophy.
Title: Wnt3a upregulation is involved in TGFβ1-induced cardiac hypertrophy.
Hypoxia exacerbates cardiomyocyte injury via upregulation of Wnt3a and inhibition of Sirt3.
Title: Hypoxia exacerbates cardiomyocyte injury via upregulation of Wnt3a and inhibition of Sirt3.
YAP and Wnt3a independently promote AECIIs proliferation and differentiation by increasing nuclear betacatenin expression in experimental bronchopulmonary dysplasia.
Title: YAP and Wnt3a independently promote AECIIs proliferation and differentiation by increasing nuclear β‑catenin expression in experimental bronchopulmonary dysplasia.
Epigenetic Regulation of WNT3A Enhancer during Regeneration of Injured Cortical Neurons.
Title: Epigenetic Regulation of WNT3A Enhancer during Regeneration of Injured Cortical Neurons.
WNT3A Promotes Neuronal Regeneration upon Traumatic Brain Injury.
Title: WNT3A Promotes Neuronal Regeneration upon Traumatic Brain Injury.
microRNA-497 inhibition mitigates myocardial infarction via enhancing wingless/integrated signal pathway in bone marrow mesenchymal stem cells.
Title: microRNA-497 inhibition mitigates myocardial infarction via enhancing wingless/integrated signal pathway in bone marrow mesenchymal stem cells.
Results provide a new evidence that miR-27b-3p regulates the signaling pathway of Wnt/beta-Catenin by targeting Wnt3a, which may play an important role in the development of atrial fibrosis and AF.
Title: Overexpression of miR-27b-3p Targeting Wnt3a Regulates the Signaling Pathway of Wnt/β-Catenin and Attenuates Atrial Fibrosis in Rats with Atrial Fibrillation.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt3a (e-PCR), detects polymorphism
- UniSTS:465420

BF390303 (e-PCR)
- UniSTS:249434

Wnt3a (e-PCR), detects polymorphism
- UniSTS:259459

Wnt3a (e-PCR), detects polymorphism
- UniSTS:508415

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in COP9 signalosome assembly	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway involved in forebrain neuroblast division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axis elongation involved in somitogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in calcium ion transmembrane transport via low voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in midbrain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in midbrain development	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within paraxial mesodermal cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of collateral sprouting in absence of injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dermatome development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesodermal cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-anal tail morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of RNA biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord association neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Wnt-Frizzled-LRP5/6 complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Wnt-3a

Names: wingless-related MMTV integration site 3A; wingless-type MMTV integration site family, member 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.