Dusp26 dual specificity phosphatase 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp26provided by MGI
Official Full Name: dual specificity phosphatase 26provided by MGI
Primary source: MGI:MGI:1914209
See related: Ensembl:ENSMUSG00000039661 AllianceGenome:MGI:1914209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Skrp3; 2310043K02Rik
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; p53 binding activity; and phosphatase activity. Predicted to be involved in several processes, including negative regulation of ERK1 and ERK2 cascade; protein dephosphorylation; and regulation of protein modification process. Located in mitochondrion. Is expressed in limb; nervous system; neural retina; and spleen. Orthologous to human DUSP26 (dual specificity phosphatase 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 32.4), cortex adult (RPKM 25.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A3; 8 17.93 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (31579555..31587074)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (31089527..31097046)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DUSP26 might be a promising therapeutic target for developing effective treatments against Diabetic nephropathy progression.
Title: DUSP26 regulates podocyte oxidative stress and fibrosis in a mouse model with diabetic nephropathy through the mediation of ROS.
expression decreased in the liver tissue of mice with hepatic steatosis and genetically obese mice
Title: Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression.
these data suggest that adipsin/C3a and DUSP26-directed therapies may represent a novel approach to achieve beta cell health to treat and prevent type 2 diabetes.
Title: Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.
DUSP26 down-regulation is an effective antineoplastic neuroblastoma strategy through activation of the p53 and p38 MAPK tumor-suppressor pathways.
Title: NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis.
results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth.
Title: The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase 26

Names: dual specificity phosphatase 26 (putative); dual-specificity phosphatase SKRP3

NP_001344152.1

EC 3.1.3.16

EC 3.1.3.48

NP_080145.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357223.1 → NP_001344152.1 dual specificity protein phosphatase 26

Status: VALIDATED

Source sequence(s)

AC109163

Consensus CDS

CCDS22219.1

UniProtKB/Swiss-Prot

Q8VCZ5, Q9D700

Related

ENSMUSP00000124949.2, ENSMUST00000161713.2

Conserved Domains (1) summary

cd00127
Location:61 → 202

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_025869.4 → NP_080145.1 dual specificity protein phosphatase 26

See identical proteins and their annotated locations for NP_080145.1

Status: VALIDATED

Source sequence(s)

AC109163, AK009781, BY150541, BY648474

Consensus CDS

CCDS22219.1

UniProtKB/Swiss-Prot

Q8VCZ5, Q9D700

Related

ENSMUSP00000046794.8, ENSMUST00000036631.14

Conserved Domains (1) summary

cd00127
Location:61 → 202

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...