Hcrt hypocretin neuropeptide precursor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hcrtprovided by RGD
Official Full Name: hypocretin neuropeptide precursorprovided by RGD
Primary source: RGD:2786
See related: Ensembl:ENSRNOG00000018892 AllianceGenome:RGD:2786
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: orexin-A
Summary: Enables neuropeptide hormone activity; type 1 hypocretin receptor binding activity; and type 2 hypocretin receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of metal ion transport; and regulation of transmission of nerve impulse. Located in secretory granule. Biomarker of hyperglycemia and obesity. Human ortholog(s) of this gene implicated in narcolepsy. Orthologous to human HCRT (hypocretin neuropeptide precursor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 9.9) and Testes (RPKM 2.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86190289..86191524, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85689979..85691214, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88669216..88670430, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells.
Title: Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells.
The effect of orexin on the hypoxic ventilatory response of female rats is greatest in the active phase during diestrus.
Title: The effect of orexin on the hypoxic ventilatory response of female rats is greatest in the active phase during diestrus.
Core body temperature varies according to the time of exercise without affecting orexin-A production in the dorsal hypothalamus in male rats.
Title: Core body temperature varies according to the time of exercise without affecting orexin-A production in the dorsal hypothalamus in male rats.
Overexpression of ORX or MCH Protects Neurological Function Against Ischemic Stroke.
Title: Overexpression of ORX or MCH Protects Neurological Function Against Ischemic Stroke.
Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
Title: Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-kappaB and MAPK signaling pathways in cerebral ischemia/reperfusion injury.
Title: Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-κB and MAPK signaling pathways in cerebral ischemia/reperfusion injury.
Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system.
Title: Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system.
Daily coordination of orexinergic gating in the rat superior colliculus-Implications for intrinsic clock activities in the visual system.
Title: Daily coordination of orexinergic gating in the rat superior colliculus-Implications for intrinsic clock activities in the visual system.
Role of Hypocretin in the Medial Preoptic Area in the Regulation of Sleep, Maternal Behavior and Body Temperature of Lactating Rats.
Title: Role of Hypocretin in the Medial Preoptic Area in the Regulation of Sleep, Maternal Behavior and Body Temperature of Lactating Rats.
Orexin-A up-regulates dopamine D2 receptor and mRNA in the nucleus accumbens Shell.
Title: Orexin-A up-regulates dopamine D2 receptor and mRNA in the nucleus accumbens Shell.

Submit: New GeneRIF Correction See all GeneRIFs (195)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC18213P1 (e-PCR)
- UniSTS:271676

RH139482 (e-PCR)
- UniSTS:221568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed
enables type 1 orexin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 orexin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 2 orexin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 orexin receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral fear response	NAS Non-traceable Author Statement more info	PubMed
involved_in eating behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transmission of nerve impulse	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transmission of nerve impulse	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transmission of nerve impulse	IDA Inferred from Direct Assay more info	PubMed
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sleep	IBA Inferred from Biological aspect of Ancestor more info
involved_in temperature homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in temperature homeostasis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in neuronal dense core vesicle lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hypocretin neuropeptide precursor

Names: Hypocretin (orexin) neuropeptide; orexin; prepro-orexin; preprohypocretin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.