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    Tmem174 transmembrane protein 174 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499516, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tmem174provided by RGD
    Official Full Name
    transmembrane protein 174provided by RGD
    Primary source
    RGD:1561129
    See related
    Ensembl:ENSRNOG00000015472 AllianceGenome:RGD:1561129
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human TMEM174 (transmembrane protein 174). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 935.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem174 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31695051..31738819, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29992070..29993601, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (28748706..28750237, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120100554 Neighboring gene uncharacterized LOC134485825 Neighboring gene uncharacterized LOC108349927

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification. Miyazaki-Anzai S, et al. J Am Soc Nephrol, 2022 Aug. PMID 35459732, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 174

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024298.1 → NP_001019469.1  transmembrane protein 174

      See identical proteins and their annotated locations for NP_001019469.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079357
      UniProtKB/Swiss-Prot
      Q68FU0
      Related
      ENSRNOP00000020879.3, ENSRNOT00000020879.6
      Conserved Domains (1) summary
      pfam15029
      Location:10 → 241
      DUF4526; Protein of unknown function (DUF4526)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      31695051..31738819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282345.1 → XP_063138415.1  transmembrane protein 174 isoform X2

      UniProtKB/Swiss-Prot
      Q68FU0

    2. XM_063282344.1 → XP_063138414.1  transmembrane protein 174 isoform X1

      UniProtKB/TrEMBL
      A6I546
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FU0.1 GenPept UniProtKB/Swiss-Prot:Q68FU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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