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    Gucy2c guanylate cyclase 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25711, updated on 2-May-2024

    Summary

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    Symbol
    Gucy2cprovided by RGD
    Full Name
    guanylate cyclase 2Cprovided by RGD
    Primary source
    RGD:2771
    See related
    Ensembl:ENSRNOG00000009031 AllianceGenome:RGD:2771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GCC
    Summary
    Enables guanylate cyclase activity and toxic substance binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 15.0), Spleen (RPKM 3.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q43
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171299715..171380296, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169568505..169649092, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170659993..170740274, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549638 Neighboring gene activating transcription factor 7 interacting protein Neighboring gene phospholipase B domain containing 1 Neighboring gene uncharacterized LOC134486648 Neighboring gene uncharacterized LOC134486649 Neighboring gene H2A.J histone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Guanylyl cyclase is a heat-stable enterotoxin receptor. Schulz S, et al. Cell, 1990 Nov 30. PMID 1701694
    2. Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet. Hasegawa K, et al. Endocr J, 2015. PMID 26249840
    3. Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet. Akieda-Asai S, et al. J Lipid Res, 2013 Jan. PMID 23081987, Free PMC Article
    4. The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor). Qian X, et al. Am J Physiol Renal Physiol, 2011 Feb. PMID 21106860, Free PMC Article
    5. Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice. Schulz S, et al. J Clin Invest, 1997 Sep 15. PMID 9294128, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance
      Title: Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
    2. Data (including data from studies in transgenic rats) suggest guanylin--guanylyl cyclase-C signaling in macrophages in mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric panniculitis/obesity via down-regulation of proinflammatory factors.
      Title: Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet.
    3. the macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity
      Title: Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet.
    4. these studies provide a comprehensive description of Ugn and GC-C expression in the kidney of the Sprague-Dawley rat.
      Title: The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).
    5. the role of the linker region in receptor guanylyl cyclases
      Title: The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables toxic substance binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanylyl cyclase C
    Names
    GC-C
    Guanylate cyclase 2C (heat stable enterotoxin receptor)
    STA receptor
    heat-stable enterotoxin receptor
    intestinal guanylate cyclase
    NP_037302.1
    XP_038963065.1
    XP_038963066.1
    XP_063141704.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013170.1 → NP_037302.1  guanylyl cyclase C precursor

      See identical proteins and their annotated locations for NP_037302.1

      Status: PROVISIONAL

      Source sequence(s)
      M55636
      UniProtKB/Swiss-Prot
      P23897
      UniProtKB/TrEMBL
      A0A8I6ACF0, A6IMI1
      Related
      ENSRNOP00000012212.5, ENSRNOT00000012212.6
      Conserved Domains (5) summary
      smart00044
      Location:787 → 978
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      smart00221
      Location:501 → 744
      STYKc; Protein kinase; unclassified specificity
      pfam00211
      Location:814 → 1001
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      cl10011
      Location:34 → 414
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:479 → 749
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      171299715..171380296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107137.2 → XP_038963065.1  guanylyl cyclase C isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACF0
      Conserved Domains (3) summary
      smart00044
      Location:674 → 865
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl10011
      Location:1 → 301
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:366 → 636
      PKc_like; Protein Kinases, catalytic domain

    2. XM_063285634.1 → XP_063141704.1  guanylyl cyclase C isoform X1

    3. XM_039107138.2 → XP_038963066.1  guanylyl cyclase C isoform X3

      UniProtKB/TrEMBL
      A6IMI3
      Conserved Domains (3) summary
      smart00044
      Location:454 → 645
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cl10011
      Location:1 → 81
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:146 → 416
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23897.2 GenPept UniProtKB/Swiss-Prot:P23897

    Gene LinkOut

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