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    Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298423, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cyp4a3provided by RGD
    Official Full Name
    cytochrome P450, family 4, subfamily a, polypeptide 3provided by RGD
    Primary source
    RGD:631356
    See related
    Ensembl:ENSRNOG00000066878 AllianceGenome:RGD:631356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CYPIVA3; Cyp4a14
    Summary
    Enables alkane 1-monooxygenase activity and arachidonic acid monooxygenase activity. Involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Located in intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 7330.7) and Liver (RPKM 3198.1) See more
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    Genomic context

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    Location:
    5q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134334396..134352268, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129097571..129115488, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134468666..134484851, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 2, pseudogene 2 Neighboring gene pyruvate kinase M1/2, pseudogene 13 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 1 Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1 Neighboring gene uncharacterized LOC134486968

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats. Imaoka S, et al. Biochem Biophys Res Commun, 1988 Apr 29. PMID 3365247
    2. Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. Wang MH, et al. Am J Physiol Renal Physiol, 2003 Aug. PMID 12684227
    3. The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes. Kimura S, et al. DNA, 1989 Sep. PMID 2766933
    4. Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450. Imaoka S, et al. Arch Biochem Biophys, 1990 Feb 1. PMID 2306108
    5. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Zhang X, et al. Proc Natl Acad Sci U S A, 2017 Mar 21. PMID 28270609, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study provides a link between CYP4A14 and NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, HFD- and MCD-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced NASH.
      Title: Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.
    2. NO differentially regulates the function of CYP4A1, -4A2, and -4A3 isoforms in the renal vasculature and the nephron.
      Title: Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat.
    3. identification of the specific pattern of cytochrome P450-4A isoform expression in arterioles and parenchymal cells of the skeletal muscle microcirculation reveals that CYP450-4A3 mRNA was expressed in isolated muscle fibers and in cremasteric arterioles
      Title: Expression of cytochrome P450-4A isoforms in the rat cremaster muscle microcirculation.
    4. that NO interacts with CYP4A proteins in a distinct manner and it interferes with renal microvessel 20-HETE synthesis, which may play an important role in the regulation of blood pressure and renal function during pregnancy.
      Title: Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkane 1-monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arachidonic acid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonic acid monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in icosanoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in icosanoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kidney development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kidney development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lauric acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lauric acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in linoleic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in linoleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to 3-methylcholanthrene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4A14
    Names
    CYPIVA14
    P450-LA-omega 3
    cytochrome P450 4A3
    cytochrome P450, family 4, subfamily a, polypeptide 14
    cytochrome P450-LA-omega 3
    long-chain fatty acid omega-monooxygenase
    NP_786936.1
    XP_038965516.1
    XP_038965517.1
    XP_038965518.1
    XP_063143470.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175760.2 → NP_786936.1  cytochrome P450 4A14

      See identical proteins and their annotated locations for NP_786936.1

      Status: PROVISIONAL

      Source sequence(s)
      M33936
      UniProtKB/Swiss-Prot
      P20817
      UniProtKB/TrEMBL
      F1M7X1
      Related
      ENSRNOP00000041025.6, ENSRNOT00000051385.7
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 502
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134334396..134352268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287400.1 → XP_063143470.1  cytochrome P450 4A14 isoform X2

      UniProtKB/TrEMBL
      A6JZ41, D3ZHZ6

    2. XM_039109590.2 → XP_038965518.1  cytochrome P450 4A14 isoform X1

      UniProtKB/TrEMBL
      F1M7X1
      Conserved Domains (1) summary
      cd20678
      Location:69 → 506
      CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z

    3. XM_039109589.2 → XP_038965517.1  cytochrome P450 4A14 isoform X1

      UniProtKB/TrEMBL
      F1M7X1
      Conserved Domains (1) summary
      cd20678
      Location:69 → 506
      CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z

    4. XM_039109588.2 → XP_038965516.1  cytochrome P450 4A14 isoform X1

      UniProtKB/TrEMBL
      F1M7X1
      Conserved Domains (1) summary
      cd20678
      Location:69 → 506
      CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20817.2 GenPept UniProtKB/Swiss-Prot:P20817

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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