Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b10provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 10provided by RGD
Primary source: RGD:69231
See related: Ensembl:ENSRNOG00000003049 AllianceGenome:RGD:69231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ABAD; ERAB; MHBD; HSD10; Hadh2
Summary: Enables several functions, including amyloid-beta binding activity; estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in Leydig cell differentiation and cell aging. Located in mitochondrion. Human ortholog(s) of this gene implicated in chromosome Xp11.22 duplication syndrome; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1394.2), Kidney (RPKM 1327.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (24568551..24571012)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (21089142..21091603)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (21696796..21699241)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that 17beta-HSD-10 is a major product of both fetal and adult-type Leydig cells.
Title: Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134351 (e-PCR)
- UniSTS:217633

RH142896 (e-PCR)
- UniSTS:232143

RH138828 (e-PCR)
- UniSTS:220915

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables acetoacetyl-CoA reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables cholate 7-alpha-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables cholate 7-alpha-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables cholate 7-alpha-dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables testosterone dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables testosterone dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables testosterone dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase [NAD(P)+] activity	ISS Inferred from Sequence or Structural Similarity more info
enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone metabolic process	IEA Inferred from Electronic Annotation more info
involved_in C21-steroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in C21-steroid hormone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in Leydig cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in androgen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in androgen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in brexanolone metabolic process	IEA Inferred from Electronic Annotation more info
involved_in brexanolone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in brexanolone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoleucine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoleucine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial tRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial tRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial tRNA 5'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial tRNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 5'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial ribonuclease P complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial ribonuclease P complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial ribonuclease P complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA methyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of tRNA methyltransferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3-hydroxyacyl-CoA dehydrogenase type-2

Names: 17-beta-HSD 10; 17-beta-estradiol 17-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase 10; 17I(2)-hydroxysteroid dehydrogenase type 10; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; amyloid beta-peptide binding protein; amyloid-beta peptide binding alcohol dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; hydroxyacyl-Coenzyme A dehydrogenase, type II; mitochondrial RNase P protein 2; mitochondrial ribonuclease P protein 2; short chain L-3-hydroxyacyl-CoA dehydrogenase; short chain dehydrogenase/reductase family 5C member 1; short-chain type dehydrogenase/reductase XH98G2; type II HADH

NP_113870.1

EC 1.1.1.159

EC 1.1.1.178

EC 1.1.1.239

EC 1.1.1.35

EC 1.1.1.53

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031682.2 → NP_113870.1 3-hydroxyacyl-CoA dehydrogenase type-2

See identical proteins and their annotated locations for NP_113870.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

O70351, Q9QYD4

UniProtKB/TrEMBL

B0BMW2, F1LNT4

Related

ENSRNOP00000091740.1, ENSRNOT00000097715.1

Conserved Domains (2) summary

cd05371
Location:9 → 261

HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs

PRK05557
Location:7 → 260

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated