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    Nhsl3 NHS like 3 [ Mus musculus (house mouse) ]

    Gene ID: 97130, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nhsl3provided by MGI
    Official Full Name
    NHS like 3provided by MGI
    Primary source
    MGI:MGI:2140651
    See related
    Ensembl:ENSMUSG00000050390 AllianceGenome:MGI:2140651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C77080; mKIAA1522
    Summary
    Predicted to be involved in cell differentiation. Orthologous to human KIAA1522 (KIAA1522). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 89.1), duodenum adult (RPKM 85.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nhsl3 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.11 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129113371..129155194, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129219578..129261404, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene S100P binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3517 Neighboring gene STARR-seq mESC enhancer starr_11478 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_11480 Neighboring gene STARR-seq mESC enhancer starr_11482 Neighboring gene predicted gene 12976 Neighboring gene STARR-positive B cell enhancer ABC_E7991 Neighboring gene syncoilin Neighboring gene retinoblastoma binding protein 4, chromatin remodeling factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129012802-129012911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129013051-129013391 Neighboring gene zinc finger and BTB domain containing 8 opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    NHS-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033189.4 → NP_001028361.1  NHS-like protein 3 isoform a

      See identical proteins and their annotated locations for NP_001028361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS18686.1
      UniProtKB/Swiss-Prot
      A2A7S8
      Related
      ENSMUSP00000062395.6, ENSMUST00000052602.6
      Conserved Domains (1) summary
      PRK14951
      Location:847 → 1006
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    2. NM_001285865.2 → NP_001272794.1  NHS-like protein 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS71475.1
      UniProtKB/Swiss-Prot
      A2A7S8
      Related
      ENSMUSP00000095483.4, ENSMUST00000097873.10
      Conserved Domains (1) summary
      PRK14951
      Location:802 → 961
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    3. NM_001285866.2 → NP_001272795.1  NHS-like protein 3 isoform c

      See identical proteins and their annotated locations for NP_001272795.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL606977
      Consensus CDS
      CCDS71474.1
      UniProtKB/Swiss-Prot
      A2A7S8, A2A7S9, Q3U356, Q3U437, Q3V3N0, Q6ZPN9, Q8K0K8
      Related
      ENSMUSP00000101666.2, ENSMUST00000106051.8
      Conserved Domains (1) summary
      PRK14951
      Location:790 → 949
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    4. NM_001285867.2 → NP_001272796.1  NHS-like protein 3 isoform d

      See identical proteins and their annotated locations for NP_001272796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL606977, AL607123
      UniProtKB/Swiss-Prot
      A2A7S8
      Conserved Domains (1) summary
      PRK14951
      Location:677 → 836
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129113371..129155194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A7S8.1 GenPept UniProtKB/Swiss-Prot:A2A7S8

    Gene LinkOut

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