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    Phlda2 pleckstrin homology-like domain, family A, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293637, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Phlda2provided by RGD
    Official Full Name
    pleckstrin homology-like domain, family A, member 2provided by RGD
    Primary source
    RGD:1304755
    See related
    Ensembl:ENSRNOG00000020614 AllianceGenome:RGD:1304755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in placenta development. Predicted to act upstream of or within several processes, including regulation of glycogen metabolic process; regulation of growth hormone activity; and regulation of spongiotrophoblast cell proliferation. Predicted to be located in cytoplasm. Orthologous to human PHLDA2 (pleckstrin homology like domain family A member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 15.6), Liver (RPKM 4.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phlda2 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208126302..208127241, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198696897..198699292, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216701345..216704479, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase inhibitor 1C Neighboring gene solute carrier family 22, member 18 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC134483952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Placental overgrowth in mice lacking the imprinted gene Ipl. Frank D, et al. Proc Natl Acad Sci U S A, 2002 May 28. PMID 12032310, Free PMC Article
    2. The imprinted Phlda2 gene regulates extraembryonic energy stores. Tunster SJ, et al. Mol Cell Biol, 2010 Jan. PMID 19884348, Free PMC Article
    3. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Tunster SJ, et al. Dev Biol, 2016 Jan 1. PMID 26476147, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in placenta development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family A member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100521.1 → NP_001093991.1  pleckstrin homology-like domain family A member 2 isoform 1

      See identical proteins and their annotated locations for NP_001093991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0T2W6, A6HYC0, F1LME7
      Related
      ENSRNOP00000027972.5, ENSRNOT00000027972.5
      Conserved Domains (2) summary
      smart00233
      Location:12 → 102
      PH; Pleckstrin homology domain
      pfam00169
      Location:12 → 102
      PH; PH domain

    2. NM_001170480.1 → NP_001163951.1  pleckstrin homology-like domain family A member 2 isoform 2

      See identical proteins and their annotated locations for NP_001163951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYB9
      Conserved Domains (1) summary
      smart00233
      Location:12 → 102
      PH; Pleckstrin homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208126302..208127241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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