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    Otulinl OTU deubiquitinase with linear linkage specificity like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310190, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Otulinlprovided by RGD
    Official Full Name
    OTU deubiquitinase with linear linkage specificity likeprovided by RGD
    Primary source
    RGD:1563205
    See related
    Ensembl:ENSRNOG00000012109 AllianceGenome:RGD:1563205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam105a
    Summary
    Predicted to be located in cytoplasm. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to colocalize with nuclear envelope. Orthologous to human OTULINL (OTU deubiquitinase with linear linkage specificity like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 364.0), Spleen (RPKM 166.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (80136411..80164290, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (78405994..78433860, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (80383642..80408672, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100754 Neighboring gene ANKH inorganic pyrophosphate transport regulator Neighboring gene OTU deubiquitinase with linear linkage specificity Neighboring gene trio Rho guanine nucleotide exchange factor Neighboring gene uncharacterized LOC134485866 Neighboring gene ribosomal protein L19, pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. Ceccarelli DF, et al. Structure, 2019 Jun 4. PMID 31056421, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124675

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables ubiquitin-like protein peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables ubiquitin-like protein peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inactive ubiquitin thioesterase OTULINL
    Names
    family with sequence similarity 105, member A
    inactive ubiquitin thioesterase FAM105A
    protein FAM105A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037648.1 → NP_001032737.1  inactive ubiquitin thioesterase OTULINL

      See identical proteins and their annotated locations for NP_001032737.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107649
      UniProtKB/Swiss-Prot
      Q3B7D8
      UniProtKB/TrEMBL
      A0A8I6AC08
      Related
      ENSRNOP00000095953.1, ENSRNOT00000096292.1
      Conserved Domains (1) summary
      pfam16218
      Location:86 → 352
      Peptidase_C101; Peptidase family C101

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      80136411..80164290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102220.2 → XP_038958148.1  inactive ubiquitin thioesterase OTULINL isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC08
      Conserved Domains (1) summary
      pfam16218
      Location:86 → 311
      Peptidase_C101; Peptidase family C101

    2. XM_039102221.2 → XP_038958149.1  inactive ubiquitin thioesterase OTULINL isoform X3

      UniProtKB/TrEMBL
      A0A8I6AC08
      Related
      ENSRNOP00000090546.1
      Conserved Domains (1) summary
      pfam16218
      Location:41 → 307
      Peptidase_C101; Peptidase family C101

    3. XM_063281751.1 → XP_063137821.1  inactive ubiquitin thioesterase OTULINL isoform X4

    4. XM_039102219.2 → XP_038958147.1  inactive ubiquitin thioesterase OTULINL isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7F3, A0A8I6AC08
      Related
      ENSRNOP00000089086.1
      Conserved Domains (1) summary
      pfam16218
      Location:79 → 345
      Peptidase_C101; Peptidase family C101

    5. XM_039102222.2 → XP_038958150.1  inactive ubiquitin thioesterase OTULINL isoform X5

      Conserved Domains (1) summary
      pfam16218
      Location:23 → 214
      Peptidase_C101; Peptidase family C101

    6. XM_039102224.2 → XP_038958152.1  inactive ubiquitin thioesterase OTULINL isoform X6

      Conserved Domains (1) summary
      pfam16218
      Location:86 → 163
      Peptidase_C101; Peptidase family C101

    7. XM_039102223.2 → XP_038958151.1  inactive ubiquitin thioesterase OTULINL isoform X6

      Conserved Domains (1) summary
      pfam16218
      Location:86 → 163
      Peptidase_C101; Peptidase family C101
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7D8.1 GenPept UniProtKB/Swiss-Prot:Q3B7D8

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