Syne1 spectrin repeat containing nuclear envelope protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Syne1provided by RGD
Full Name: spectrin repeat containing nuclear envelope protein 1provided by RGD
Primary source: RGD:620546
See related: Ensembl:ENSRNOG00000018960 AllianceGenome:RGD:620546
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CPG2; Myne-1
Summary: Enables enzyme binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of mesenchymal cell apoptotic process; negative regulation of mini excitatory postsynaptic potential; and regulation of receptor-mediated endocytosis. Located in several cellular components, including dendritic spine head; midbody; and nuclear membrane. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 659.2), Lung (RPKM 334.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 150

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (43917640..44388802, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (41512146..41983382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (41844840..42086662, complement) , (41608287..41763591, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
Title: Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
Through direct interactions with F-actin and EndoB2, CPG2 physically bridges the spine cytoskeleton and the endocytic machinery, and this tripartite association is critical specifically for activity-dependent clathrin-mediated endocytosis of synaptic glutamate receptors.
Title: CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors.
the expression of nesprin-1 protein was higher during the differentiation process of MSCs and may have an important role in mediating MSC differentiation.
Title: Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro.
In the process of mesenchymal stem cell proliferation and differentiation, the upregulation of the protein expression of nesprin-1 may maintain the stability of the cell nuclear membrane and reduce the apoptosis of the mesenchymal stem cells.
Title: Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells.
CPG2 regulates synaptic AMPAR endocytosis through its association with the spine cytoskeleton and functions as a nexus for integrating PKA signaling with this process.
Title: Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.
Through the direct binding of the nesprin-1alpha amino-terminal dimerization domain to the third mAKAP spectrin repeat, nesprin-1alpha targets mAKAP to the nuclear envelope.
Title: Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope.
CPG2 is a key component of a specialized postsynaptic endocytic mechanism devoted to the internalization of synaptic proteins, including glutamate receptors.
Title: CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors.
role for in facilitating retrograde vesicular trafficking from the Golgi to the ER
Title: The spectrin family member Syne-1 functions in retrograde transport from Golgi to ER.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134376 (e-PCR)
- UniSTS:217658

D1Got41 (e-PCR)
- UniSTS:114541

D1Got40 (e-PCR)
- UniSTS:112855

RH139857 (e-PCR)
- UniSTS:221941

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cytoskeleton-nuclear membrane anchor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mini excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear matrix anchoring at nuclear membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine head	IDA Inferred from Direct Assay more info	PubMed
part_of meiotic nuclear membrane microtubule tethering complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nesprin-1

Names: nesprin-1-like; spectrin repeat containing, nuclear envelope 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419849.1 → NP_001406778.1 nesprin-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

43917640..44388802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270573.1 → XP_063126643.1 nesprin-1 isoform X9
XM_063270583.1 → XP_063126653.1 nesprin-1 isoform X12
XM_063270581.1 → XP_063126651.1 nesprin-1 isoform X12
XM_063270574.1 → XP_063126644.1 nesprin-1 isoform X10
XM_039101500.2 → XP_038957428.1 nesprin-1 isoform X9

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1151 → 1585

PTZ00121; MAEBL; Provisional

COG1196
Location:1404 → 2254

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7993 → 8203

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4951 → 5786

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4411 → 5236

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8753 → 8809

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2398 → 2603

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101511.2 → XP_038957439.1 nesprin-1 isoform X29

UniProtKB/TrEMBL

A0A5P8DHK4

Conserved Domains (9) summary

PTZ00121
Location:1161 → 1595

PTZ00121; MAEBL; Provisional

COG1196
Location:1414 → 2264

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7951 → 8161

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4961 → 5796

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4421 → 5246

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8663 → 8719

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 136

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:175 → 283

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2408 → 2613

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101503.2 → XP_038957431.1 nesprin-1 isoform X15

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1161 → 1595

PTZ00121; MAEBL; Provisional

COG1196
Location:1414 → 2264

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7998 → 8208

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4961 → 5796

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4421 → 5246

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8735 → 8791

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 136

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:175 → 283

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2408 → 2613

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101499.2 → XP_038957427.1 nesprin-1 isoform X7

UniProtKB/TrEMBL

A0A5P8DHN0, A0A8I5ZJB9

Related

ENSRNOP00000076933.1

Conserved Domains (9) summary

PTZ00121
Location:1161 → 1595

PTZ00121; MAEBL; Provisional

COG1196
Location:1414 → 2264

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7998 → 8208

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4961 → 5796

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4421 → 5246

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8758 → 8814

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 136

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:175 → 283

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2408 → 2613

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101497.2 → XP_038957425.1 nesprin-1 isoform X5

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1161 → 1595

PTZ00121; MAEBL; Provisional

COG1196
Location:1414 → 2264

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4961 → 5796

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4421 → 5246

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8763 → 8819

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 136

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:175 → 283

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2408 → 2613

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063270618.1 → XP_063126688.1 nesprin-1 isoform X24
XM_017590500.3 → XP_017445989.2 nesprin-1 isoform X23

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (8) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8010 → 8220

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101509.2 → XP_038957437.1 nesprin-1 isoform X21

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (8) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8010 → 8220

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101506.2 → XP_038957434.1 nesprin-1 isoform X19

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7958 → 8168

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4916 → 5751

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4376 → 5201

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8718 → 8774

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101510.2 → XP_038957438.1 nesprin-1 isoform X22

UniProtKB/TrEMBL

A0A5P8DHK4

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7958 → 8168

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8670 → 8726

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063270600.1 → XP_063126670.1 nesprin-1 isoform X18
XM_039101504.2 → XP_038957432.1 nesprin-1 isoform X16

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7963 → 8173

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8723 → 8779

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101496.2 → XP_038957424.1 nesprin-1 isoform X4

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8005 → 8215

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8765 → 8821

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101495.2 → XP_038957423.1 nesprin-1 isoform X3

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8006 → 8216

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8766 → 8822

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101494.2 → XP_038957422.1 nesprin-1 isoform X2

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8009 → 8219

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8769 → 8825

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063270606.1 → XP_063126676.1 nesprin-1 isoform X20
XM_039101505.2 → XP_038957433.1 nesprin-1 isoform X17

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8010 → 8220

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8722 → 8778

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101502.2 → XP_038957430.1 nesprin-1 isoform X11

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8010 → 8220

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8747 → 8803

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101493.2 → XP_038957421.1 nesprin-1 isoform X1

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8010 → 8220

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8770 → 8826

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063270562.1 → XP_063126632.1 nesprin-1 isoform X5
XM_039101492.2 → XP_038957420.1 nesprin-1 isoform X1

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1168 → 1602

PTZ00121; MAEBL; Provisional

COG1196
Location:1421 → 2271

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8010 → 8220

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4968 → 5803

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4428 → 5253

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8770 → 8826

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2415 → 2620

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063270589.1 → XP_063126659.1 nesprin-1 isoform X14
XM_063270568.1 → XP_063126638.1 nesprin-1 isoform X8
XM_063270587.1 → XP_063126657.1 nesprin-1 isoform X13
XM_039101498.2 → XP_038957426.1 nesprin-1 isoform X6

UniProtKB/TrEMBL

A0A5P8DHN0

Conserved Domains (9) summary

PTZ00121
Location:1159 → 1593

PTZ00121; MAEBL; Provisional

COG1196
Location:1412 → 2262

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8001 → 8211

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4959 → 5794

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:4419 → 5244

CCDC158; Coiled-coil domain-containing protein 158

pfam10541
Location:8761 → 8817

KASH; Nuclear envelope localization domain

cd21241
Location:15 → 134

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:173 → 281

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:2406 → 2611

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063270623.1 → XP_063126693.1 nesprin-1 isoform X25
XM_006227851.5 → XP_006227913.1 nesprin-1 isoform X26

UniProtKB/TrEMBL

Q8VHJ9

Conserved Domains (4) summary

COG1196
Location:219 → 965

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2222 → 2432

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:2959 → 3015

KASH; Nuclear envelope localization domain

cl02488
Location:186 → 409

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006227852.5 → XP_006227914.1 nesprin-1 isoform X28

UniProtKB/TrEMBL

A0A8I6B1X1, A6KIM8

Related

ENSRNOP00000095051.1

Conserved Domains (2) summary

cd00176
Location:155 → 365

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:892 → 948

KASH; Nuclear envelope localization domain
XM_063270634.1 → XP_063126704.1 nesprin-1 isoform X27

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001029909.1: Suppressed sequence

Description

NM_001029909.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.