Vamp5 vesicle-associated membrane protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vamp5provided by RGD
Official Full Name: vesicle-associated membrane protein 5provided by RGD
Primary source: RGD:620419
See related: AllianceGenome:RGD:620419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in Golgi to plasma membrane protein transport. Predicted to act upstream of or within skeletal muscle tissue development. Located in plasma membrane and trans-Golgi network. Orthologous to human VAMP5 (vesicle associated membrane protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 527.6), Heart (RPKM 175.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (105982004..105993247, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (104423813..104435059, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100231561..100232560, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VAMP2, VAMP5, and VAMP7 may be involved in translocation of GLUT4 during muscle contractions.
Title: Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140679 (e-PCR)
- UniSTS:222747

RH141198 (e-PCR)
- UniSTS:223194

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vesicle-associated membrane protein 5

Names: VAMP-5; myobrevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053555.2 → NP_446007.1 vesicle-associated membrane protein 5

See identical proteins and their annotated locations for NP_446007.1

Status: VALIDATED

Source sequence(s)

FQ127573, FQ217123, JAXUCZ010000004

UniProtKB/Swiss-Prot

Q9Z2J5

UniProtKB/TrEMBL

A0A140TAB7, A6IAB5

Conserved Domains (2) summary

cd15872
Location:5 → 70

R-SNARE_VAMP5; SNARE motif of VAMP5

pfam00957
Location:4 → 79

Synaptobrevin; Synaptobrevin