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    Acy3 aminoacylase 3 [ Mus musculus (house mouse) ]

    Gene ID: 71670, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Acy3provided by MGI
    Official Full Name
    aminoacylase 3provided by MGI
    Primary source
    MGI:MGI:1918920
    See related
    Ensembl:ENSMUSG00000024866 AllianceGenome:MGI:1918920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA3; AAIII; Acy-3; HCBP1; 0610006H10Rik
    Summary
    This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in kidney adult (RPKM 558.9), liver adult (RPKM 83.7) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acy3 in Genome Data Viewer
    Location:
    19 A; 19 3.7 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4036570..4040007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3986570..3990007)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene STARR-positive B cell enhancer ABC_E7625 Neighboring gene predicted gene, 52386 Neighboring gene T-box 10 Neighboring gene nudix hydrolase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel. Tsirulnikov K, et al. Biochim Biophys Acta, 2009 Jul. PMID 19362172, Free PMC Article
    2. Specificity of aminoacylase III-mediated deacetylation of mercapturic acids. Newman D, et al. Drug Metab Dispos, 2007 Jan. PMID 17012540
    3. Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein. Tsirulnikov K, et al. FEBS Lett, 2012 Nov 2. PMID 23010594, Free PMC Article
    4. Structures of aminoacylase 3 in complex with acetylated substrates. Hsieh JM, et al. Proc Natl Acad Sci U S A, 2010 Oct 19. PMID 20921362, Free PMC Article
    5. Structural characterization of dimeric murine aminoacylase III. Ryazantsev S, et al. FEBS Lett, 2007 May 1. PMID 17434493

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus that may by implicated in HCV pathogenesis.
      Title: Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein.
    2. structures, in conjunction with biochemical data, indicated that AA3 mediates substrate specificity through van der Waals interactions providing a dynamic interaction interface, which facilitates a diverse range of substrates
      Title: Structures of aminoacylase 3 in complex with acetylated substrates.
    3. A 16A resolution model of the AAIII dimer.
      Title: Structural characterization of dimeric murine aminoacylase III.
    4. data suggest that in kidney proximal tubules, aminoacylase III plays an important role in deacetylating mercapturic acids
      Title: Structural characterization, tissue distribution, and functional expression of murine aminoacylase III.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
    Names
    acylase III
    aminoacylase III
    aspartoacylase (aminoacylase) 3
    aspartoacylase-2
    hepatitis C virus core-binding protein 1
    NP_001289408.1
    NP_001289409.1
    NP_001289410.1
    NP_001289411.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302479.1 → NP_001289408.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1

      See identical proteins and their annotated locations for NP_001289408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA110692, AK143782
      Consensus CDS
      CCDS29406.1
      UniProtKB/Swiss-Prot
      Q3UP59, Q91XE4, Q9DD17
      Related
      ENSMUSP00000158512.2, ENSMUST00000236510.2
      Conserved Domains (2) summary
      cd06909
      Location:13 → 299
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
      pfam04952
      Location:10 → 299
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

    2. NM_001302480.1 → NP_001289409.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1

      See identical proteins and their annotated locations for NP_001289409.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA110692, AK143782
      Consensus CDS
      CCDS29406.1
      UniProtKB/Swiss-Prot
      Q3UP59, Q91XE4, Q9DD17
      Conserved Domains (2) summary
      cd06909
      Location:13 → 299
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
      pfam04952
      Location:10 → 299
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

    3. NM_001302481.1 → NP_001289410.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1

      See identical proteins and their annotated locations for NP_001289410.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA110692, AK143782
      Consensus CDS
      CCDS29406.1
      UniProtKB/Swiss-Prot
      Q3UP59, Q91XE4, Q9DD17
      Related
      ENSMUSP00000158093.2, ENSMUST00000235612.2
      Conserved Domains (2) summary
      cd06909
      Location:13 → 299
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
      pfam04952
      Location:10 → 299
      AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

    4. NM_001302482.1 → NP_001289411.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in both UTRs and lacks an alternate exon in the 5' coding region compared to variant 1, resulting in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA110692, AK143782
      UniProtKB/Swiss-Prot
      Q91XE4
      Conserved Domains (1) summary
      cl11393
      Location:13 → 79
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4036570..4040007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027857.3: Suppressed sequence

      Description
      NM_027857.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XE4.1 GenPept UniProtKB/Swiss-Prot:Q91XE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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