Gzma granzyme A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gzmaprovided by MGI
Official Full Name: granzyme Aprovided by MGI
Primary source: MGI:MGI:109266
See related: Ensembl:ENSMUSG00000023132 AllianceGenome:MGI:109266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hf; Hf1; SE1; TSP1; Ctla3; TSP-1; Ctla-3
Summary: Enables serine-type peptidase activity. Acts upstream of or within response to bacterium. Located in nucleus. Is expressed in thymus primordium. Orthologous to human GZMA (granzyme A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 10.7), thymus adult (RPKM 4.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.93 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (113230358..113237515, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (113093824..113100981, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta cells resulting in neonatal lethality.
Title: Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality.
Granzyme-A deficiency attenuates experimental osteoarthritis in mice, but perforin deficiency does not.
Title: Granzyme-A deficiency attenuates experimental osteoarthritis in mice, but perforin deficiency does not.
Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma.
Title: Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma.
gammadelta Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
Title: γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
Biological relevance of Granzymes A and K during E. coli sepsis.
Title: Biological relevance of Granzymes A and K during E. coli sepsis.
Granzyme A-producing T helper cells are critical for acute graft-versus-host disease.
Title: Granzyme A-producing T helper cells are critical for acute graft-versus-host disease.
Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
Title: Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
Granzyme A in Chikungunya and Other Arboviral Infections.
Title: Granzyme A in Chikungunya and Other Arboviral Infections.
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.
Title: Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.
GzmA and gzmB were predominantly expressed by natural killer cells, and during abdominal sepsis, the percentage of these cells expressing gzms in peritoneal lavage fluid decreased, while the amount of expression in the gzm(+) cells increased
Title: Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytotoxic T cell pyroptotic process	ISO Inferred from Sequence Orthology more info
involved_in granzyme-mediated programmed cell death signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyroptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: granzyme A

Names: BLT esterase; H factor; Hanukah factor; autocrine thymic lymphoma granzyme-like serine protease; fragmentin-1; serine esterase 1; t cell-specific serine protease 1

NP_034500.1

EC 3.4.21.78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010370.3 → NP_034500.1 granzyme A precursor

See identical proteins and their annotated locations for NP_034500.1

Status: VALIDATED

Source sequence(s)

BC061146, EH095037

Consensus CDS

CCDS26782.1

UniProtKB/Swiss-Prot

P11032, P15118

UniProtKB/TrEMBL

Q3U0N0, Q3UK79

Related

ENSMUSP00000023897.6, ENSMUST00000023897.7

Conserved Domains (2) summary

smart00020
Location:28 → 252

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:29 → 255

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...