STX7 syntaxin 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STX7provided by HGNC
Official Full Name: syntaxin 7provided by HGNC
Primary source: HGNC:HGNC:11442
See related: Ensembl:ENSG00000079950 MIM:603217; AllianceGenome:HGNC:11442
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]
Expression: Ubiquitous expression in lymph node (RPKM 31.8), spleen (RPKM 19.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q23.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (132445867..132513472, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (133640859..133708445, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (132767006..132834611, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 7 modulates seizure activity in epilepsy.
Title: Syntaxin 7 modulates seizure activity in epilepsy.
Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation.
Title: Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation.
Data suggest that accumulation of recycling T cell receptors at the immunological synapse is SNARE-dependent and that Stx7-mediated processing of recycling TCRs through endosomes is a prerequisite for the cytolytic function of cytotoxic T lymphocytes.
Title: Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes.
data reveal the presence of syntaxin 7 in the membranes of exocytosis-prone granules and phagocytosis-related granules in human neutrophils, and therefore it might play a role in both exocytosis and phagocytosis in human neutrophils
Title: Intracellular location of syntaxin 7 in human neutrophils.
The expression level of STX7 protein was inversely correlated to tumor stage, suggesting that decreased expression of STX7 is associated with more aggressive tumors.
Title: Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma.
Palmitoylation-defective syntaxin 7 is selectively retained on the plasma membrane, suggesting that palmitoylation is important for intercompartmental transport of syntaxin 7.
Title: Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8.
Results report that syntaxin 7, syntaxin 8, vti1b and VAMP8 physically and functionally interact with CFTR.
Title: Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.
syntaxin 7 has a role in the intracellular vacuolation induced by VacA
Title: Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1	PubMed
capsid	gag	Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A009O06 (e-PCR)
- UniSTS:60417

STS-W94888 (e-PCR)
- UniSTS:81163

SHGC-155523 (e-PCR)
- UniSTS:185111

RH121178 (e-PCR)
- UniSTS:134172

G32698 (e-PCR)
- UniSTS:117280

RH93946 (e-PCR)
- UniSTS:91444

WI-17521 (e-PCR)
- UniSTS:63818

RH92707 (e-PCR)
- UniSTS:89953

RH46764 (e-PCR)
- UniSTS:21617

RH103341 (e-PCR)
- UniSTS:97672

D6S2191 (e-PCR)
- UniSTS:54486

RH46806 (e-PCR)
- UniSTS:54487

D6S957 (e-PCR)
- UniSTS:149223

G28630 (e-PCR)
- UniSTS:12280

RH12578 (e-PCR)
- UniSTS:66041

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in organelle localization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in azurophil granule	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	HDA more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in tertiary granule	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: syntaxin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050740.2 RefSeqGene

Range

5356..72605

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001326578.2 → NP_001313507.1 syntaxin-7 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL357034, AL589691

Consensus CDS

CCDS5153.1

UniProtKB/Swiss-Prot

E1P579, O15400, Q5SZW2, Q96ES9

UniProtKB/TrEMBL

B4DH37

Conserved Domains (2) summary

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7

pfam14523
Location:18 → 119

Syntaxin_2; Syntaxin-like protein
NM_001326579.2 → NP_001313508.1 syntaxin-7 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AL357034, AL589691

Consensus CDS

CCDS5153.1

UniProtKB/Swiss-Prot

E1P579, O15400, Q5SZW2, Q96ES9

UniProtKB/TrEMBL

B4DH37

Conserved Domains (2) summary

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7

pfam14523
Location:18 → 119

Syntaxin_2; Syntaxin-like protein
NM_001326580.2 → NP_001313509.1 syntaxin-7 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AL357034, AL589691

Consensus CDS

CCDS87441.1

UniProtKB/Swiss-Prot

O15400

Related

ENSP00000356914.4, ENST00000367937.4

Conserved Domains (2) summary

cd00179
Location:9 → 148

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7
NM_003569.3 → NP_003560.2 syntaxin-7 isoform a

See identical proteins and their annotated locations for NP_003560.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).

Source sequence(s)

AJ420529, AL357034, AW500305, BC011975, BF064142, DA242979, U77942

Consensus CDS

CCDS5153.1

UniProtKB/Swiss-Prot

E1P579, O15400, Q5SZW2, Q96ES9

UniProtKB/TrEMBL

B4DH37

Related

ENSP00000356918.1, ENST00000367941.7

Conserved Domains (2) summary

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7

pfam14523
Location:18 → 119

Syntaxin_2; Syntaxin-like protein

RNA

NR_137169.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' end and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL357034, AL589691