Pltp phospholipid transfer protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pltpprovided by RGD
Official Full Name: phospholipid transfer proteinprovided by RGD
Primary source: RGD:1306695
See related: Ensembl:ENSRNOG00000016488 AllianceGenome:RGD:1306695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bpife
Summary: Predicted to enable several functions, including lipid transfer activity; lipoprotein particle binding activity; and phospholipid binding activity. Predicted to be involved in high-density lipoprotein particle remodeling; lipid transport; and positive regulation of cholesterol efflux. Predicted to act upstream of or within flagellated sperm motility and vitamin E biosynthetic process. Predicted to be located in extracellular region and nucleus. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Orthologous to human PLTP (phospholipid transfer protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 531.0), Kidney (RPKM 512.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173994162..174011982, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153574825..153592647, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (161304469..161322289, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lung injury was accompanied by the upregulation of PLTP and IL-8 in the CSE-exposed rat model
Title: Effect of Phospholipid Transfer Protein on Cigarette Smoke Extract-Induced IL-8 Production in Human Pulmonary Epithelial Cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048972 (e-PCR)
- UniSTS:145422

AA891893 (e-PCR)
- UniSTS:261490

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables ceramide transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables cerebroside transfer activity	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables diacylglyceride transfer activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidic acid transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylglycerol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylglycerol transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol transfer activity	ISO Inferred from Sequence Orthology more info
enables phospholipid transfer activity	ISO Inferred from Sequence Orthology more info
enables sphingomyelin transfer activity	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ceramide transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in glycolipid transport	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in sterol transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vitamin E biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipid transfer protein

Names: BPI fold containing family E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168543.1 → NP_001162015.1 phospholipid transfer protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AGE7, E9PSP1

Related

ENSRNOP00000022594.4, ENSRNOT00000022594.7

Conserved Domains (2) summary

smart00328
Location:25 → 243

BPI1; BPI/LBP/CETP N-terminal domain

cl00188
Location:228 → 464

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...