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    Fermt3 FERM domain containing kindlin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309186, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fermt3provided by RGD
    Official Full Name
    FERM domain containing kindlin 3provided by RGD
    Primary source
    RGD:1310168
    See related
    Ensembl:ENSRNOG00000021161 AllianceGenome:RGD:1310168
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310168
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in several processes, including integrin activation; integrin-mediated signaling pathway; and platelet aggregation. Predicted to be located in podosome. Predicted to be active in cell-substrate junction. Biomarker of ovarian cancer. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 417.9), Thymus (RPKM 402.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fermt3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213618691..213636889, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204189483..204207683, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222254183..222272775, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1 Neighboring gene uncharacterized LOC120099981 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene fibronectin leucine rich transmembrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Discovery of serum biomarkers implicated in the onset and progression of serous ovarian cancer in a rat model using iTRAQ technique. Huang Y, et al. Eur J Obstet Gynecol Reprod Biol, 2012 Nov. PMID 22818854
    2. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Svensson L, et al. Nat Med, 2009 Mar. PMID 19234463, Free PMC Article
    3. LAD-1/variant syndrome is caused by mutations in FERMT3. Kuijpers TW, et al. Blood, 2009 May 7. PMID 19064721
    4. Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds. Oksala N, et al. Atherosclerosis, 2015 Sep. PMID 26188538
    5. [Expression of Kindlins and angiopoietins in acute myeloid leukemia]. Wu WB, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2012 Feb. PMID 22391155

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-substrate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fermitin family homolog 3
    Names
    fermitin family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127543.1 → NP_001121015.1  fermitin family homolog 3

      See identical proteins and their annotated locations for NP_001121015.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166607
      UniProtKB/TrEMBL
      A6HZN0, B2GVB9
      Related
      ENSRNOP00000028737.4, ENSRNOT00000028737.6
      Conserved Domains (6) summary
      smart00295
      Location:221 → 301
      B41; Band 4.1 homologues
      cd01237
      Location:350 → 474
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:550 → 641
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      cd17185
      Location:98 → 254
      FERM_F1_KIND3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-3 (KIND3)
      pfam00373
      Location:462 → 555
      FERM_M; FERM central domain
      cl28922
      Location:15 → 97
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213618691..213636889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230811.5 → XP_006230873.1  fermitin family homolog 3 isoform X1

      See identical proteins and their annotated locations for XP_006230873.1

      UniProtKB/TrEMBL
      A6HZN0, B2GVB9
      Conserved Domains (6) summary
      smart00295
      Location:221 → 301
      B41; Band 4.1 homologues
      cd01237
      Location:350 → 474
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:550 → 641
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      cd17185
      Location:98 → 254
      FERM_F1_KIND3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-3 (KIND3)
      pfam00373
      Location:462 → 555
      FERM_M; FERM central domain
      cl28922
      Location:15 → 97
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_039079706.2 → XP_038935634.1  fermitin family homolog 3 isoform X2

      Conserved Domains (4) summary
      smart00295
      Location:221 → 301
      B41; Band 4.1 homologues
      cd01237
      Location:350 → 474
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd17185
      Location:98 → 254
      FERM_F1_KIND3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-3 (KIND3)
      cl28922
      Location:15 → 97
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version

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