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    Man2b1 mannosidase, alpha, class 2B, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361378, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Man2b1provided by RGD
    Official Full Name
    mannosidase, alpha, class 2B, member 1provided by RGD
    Primary source
    RGD:3039
    See related
    Ensembl:ENSRNOG00000023910 AllianceGenome:RGD:3039
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Manb
    Summary
    Enables alpha-mannosidase activity and mannose binding activity. Predicted to be involved in cellular protein modification process. Predicted to act upstream of or within learning or memory and mannose metabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 516.4), Spleen (RPKM 445.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    19q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (39959964..39979299, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23055092..23074398, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26196797..26216981)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene disks large homolog 5-like Neighboring gene uncharacterized LOC120098586 Neighboring gene zinc finger protein 791 Neighboring gene Sec61 translocon subunit gamma, pseudogene 1 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene WD repeat domain 83 Neighboring gene deoxyhypusine synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The effects of swainsonine on the activity and expression of α-mannosidase in BRL-3A cells. Lu H, et al. Toxicon, 2015 Jun 1. PMID 25797317
    2. Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis. D'Hooge R, et al. J Neurosci, 2005 Jul 13. PMID 16014715, Free PMC Article
    3. Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis. Stinchi S, et al. Hum Mol Genet, 1999 Aug. PMID 10400983
    4. Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid alpha-mannosidase. Liao YF, et al. J Biol Chem, 1996 Nov 8. PMID 8910458
    5. Lysosomal alpha-mannosidases of mouse tissues: characteristics of the isoenzymes, and cloning and expression of a full-length cDNA. Beccari T, et al. Biochem J, 1997 Oct 1. PMID 9355733, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72561

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-mannosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mannose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal alpha-mannosidase
    Names
    mannosidase 2, alpha B1
    mannosidase, alpha B, lysosomal
    NP_955436.1
    XP_006255335.1
    XP_038953745.1
    XP_038953746.1
    XP_063134183.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199404.1 → NP_955436.1  lysosomal alpha-mannosidase precursor

      See identical proteins and their annotated locations for NP_955436.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061819
      UniProtKB/TrEMBL
      Q6P762
      Conserved Domains (2) summary
      PLN02701
      Location:63 → 904
      PLN02701; alpha-mannosidase
      cd10810
      Location:63 → 340
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      39959964..39979299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097818.2 → XP_038953746.1  lysosomal alpha-mannosidase isoform X3

      Conserved Domains (2) summary
      PLN02701
      Location:63 → 905
      PLN02701; alpha-mannosidase
      cd10810
      Location:63 → 340
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

    2. XM_039097817.2 → XP_038953745.1  lysosomal alpha-mannosidase isoform X2

      UniProtKB/TrEMBL
      F7FG85
      Related
      ENSRNOP00000030766.4
      Conserved Domains (2) summary
      PLN02701
      Location:63 → 915
      PLN02701; alpha-mannosidase
      cd10810
      Location:63 → 351
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

    3. XM_006255273.5 → XP_006255335.1  lysosomal alpha-mannosidase isoform X1

      Conserved Domains (3) summary
      cd10810
      Location:63 → 351
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:399 → 477
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:617 → 1011
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

    4. XM_063278113.1 → XP_063134183.1  lysosomal alpha-mannosidase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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