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    Hectd4 HECT domain E3 ubiquitin protein ligase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304503, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hectd4provided by RGD
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 4provided by RGD
    Primary source
    RGD:1309762
    See related
    Ensembl:ENSRNOG00000001352 AllianceGenome:RGD:1309762
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309762
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in glucose homeostasis and glucose metabolic process. Orthologous to human HECTD4 (HECT domain E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 134.0), Brain (RPKM 127.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12q16
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40800232..40991584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35182165..35330935, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40712078..40860930, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095847 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene 40S ribosomal protein S27-like Neighboring gene 40S ribosomal protein S20-like Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene ribosomal protein L6 Neighboring gene protein tyrosine phosphatase, non-receptor type 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination. Zhang YY, et al. Mol Neurobiol, 2023 Mar. PMID 36527595
    2. New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. Go MJ, et al. J Hum Genet, 2013 Jun. PMID 23575436
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
      Title: The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HECTD4
    Names
    HECT domain containing E3 ubiquitin protein ligase 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40800232..40991584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089874.2 → XP_038945802.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2413 → 2568
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4033 → 4426
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_039089873.2 → XP_038945801.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2414 → 2569
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4033 → 4426
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. XM_017598533.3 → XP_017454022.2  probable E3 ubiquitin-protein ligase HECTD4 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2398 → 2553
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4018 → 4411
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    4. XM_063271893.1 → XP_063127963.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X7

    5. XM_039089875.2 → XP_038945803.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2412 → 2567
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4032 → 4425
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    6. XM_039089878.2 → XP_038945806.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Related
      ENSRNOP00000084673.1
      Conserved Domains (2) summary
      cd13735
      Location:2400 → 2555
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4020 → 4413
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    7. XM_039089877.2 → XP_038945805.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2405 → 2560
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4025 → 4418
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    8. XM_039089876.2 → XP_038945804.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2409 → 2564
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4029 → 4422
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    9. XM_039089872.2 → XP_038945800.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZM0
      Conserved Domains (2) summary
      cd13735
      Location:2414 → 2569
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:4034 → 4427
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    10. XM_039089879.2 → XP_038945807.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X10

      UniProtKB/TrEMBL
      F1LZX5
      Related
      ENSRNOP00000001826.8
      Conserved Domains (2) summary
      cd13735
      Location:1888 → 2043
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:3508 → 3901
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    11. XM_039089880.2 → XP_038945808.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X11

      UniProtKB/TrEMBL
      F1LZX5
      Conserved Domains (2) summary
      cd13735
      Location:1370 → 1525
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:2990 → 3383
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    12. XM_039089882.1 → XP_038945810.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X12

      Conserved Domains (2) summary
      cd13735
      Location:930 → 1085
      SPRY_HECT_like; SPRY domain in HECT E3
      cl27008
      Location:2550 → 2943
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RNA

    1. XR_010056783.1 RNA Sequence

    2. XR_010056782.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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