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    NR5A1 nuclear receptor subfamily 5 group A member 1 [ Bos taurus (cattle) ]

    Gene ID: 281948, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NR5A1provided by VGNC
    Official Full Name
    nuclear receptor subfamily 5 group A member 1provided by VGNC
    Primary source
    VGNC:VGNC:32248
    See related
    BGD:BT22739; Ensembl:ENSBTAG00000009017
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SF-1
    Orthologs
    human mouse all
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    Genomic context

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    See NR5A1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (95513838..95538616, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 7 Neighboring gene uncharacterized LOC112448837 Neighboring gene adhesion G protein-coupled receptor D2 Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene uncharacterized LOC100848407 Neighboring gene microRNA mir-181a-2 Neighboring gene microRNA mir-181b-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influence of 4-hydroxylated polychlorinated biphenyls on the secretory function of bovine ovarian cells: role of the steroidogenic factor-1 receptor. Mlynarczuk J, et al. Anim Reprod Sci, 2015 Apr. PMID 25726440
    2. Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells. Walther N, et al. Reprod Biol Endocrinol, 2006 Dec 19. PMID 17176485, Free PMC Article
    3. Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. Honda S, et al. J Biol Chem, 1993 Apr 5. PMID 8463279
    4. StarD7 gene expression in trophoblast cells: contribution of SF-1 and Wnt-beta-catenin signaling. Rena V, et al. Mol Endocrinol, 2011 Aug. PMID 21622533, Free PMC Article
    5. The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum. Taniguchi H, et al. Mol Reprod Dev, 2009 Sep. PMID 19455657

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that PCBs impair the secretory function of ovarian steroidogenic cells by disrupting steroidogenesis and increasing OT secretion, and the receptor SF-1 appears to be essentially involved in these processes.
      Title: Influence of 4-hydroxylated polychlorinated biphenyls on the secretory function of bovine ovarian cells: role of the steroidogenic factor-1 receptor.
    2. The SF-1 and beta-catenin pathway convergence on StarD7 expression may have important implications in the phospholipid uptake and transport, contributing to the normal trophoblast development.
      Title: StarD7 gene expression in trophoblast cells: contribution of SF-1 and Wnt-beta-catenin signaling.
    3. GATA4 and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1, NR5A2, and the other steroidogenic markers.
      Title: The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum.
    4. Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
      Title: Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
    5. The role of the NR5A1 activating functions AF-1 & AF-2 was studied in luteinizing bovine theca cells. The regulation of the 3 NR5A1-controlled genes CYPA11, STAR, & INSL3 apparently is not dependent on NR5A1 activating functions AF-1 or AF-2.
      Title: Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    steroidogenic factor 1
    Names
    STF-1
    adrenal 4-binding protein
    fushi tarazu factor homolog 1
    steroid hormone receptor Ad4BP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174403.2 → NP_776828.1  steroidogenic factor 1

      See identical proteins and their annotated locations for NP_776828.1

      Status: PROVISIONAL

      Source sequence(s)
      D13569
      UniProtKB/Swiss-Prot
      Q04752
      Related
      ENSBTAP00000011869.3, ENSBTAT00000011869.5
      Conserved Domains (2) summary
      cd07070
      Location:223 → 459
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13 → 105
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      95513838..95538616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024998291.2 → XP_024854059.1  steroidogenic factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q04752
      Conserved Domains (2) summary
      cd07070
      Location:223 → 459
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13 → 105
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    2. XM_010810325.4 → XP_010808627.1  steroidogenic factor 1 isoform X1

      See identical proteins and their annotated locations for XP_010808627.1

      UniProtKB/Swiss-Prot
      Q04752
      Conserved Domains (2) summary
      cd07070
      Location:223 → 459
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13 → 105
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04752.1 GenPept UniProtKB/Swiss-Prot:Q04752

    Gene LinkOut

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