Aldoc aldolase, fructose-bisphosphate C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldocprovided by RGD
Official Full Name: aldolase, fructose-bisphosphate Cprovided by RGD
Primary source: RGD:2091
See related: Ensembl:ENSRNOG00000011452 AllianceGenome:RGD:2091
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALDCAA; F16dip7; RATALDCAA
Summary: Enables fructose-bisphosphate aldolase activity and identical protein binding activity. Involved in several processes, including aging; animal organ regeneration; and response to hypoxia. Located in axon and cytoplasm. Is active in postsynaptic cytosol. Biomarker of borna disease and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3215.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63715544..63719133)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63217477..63221066)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65586504..65590093)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls.
Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
Dorsal column nuclei (DCN)-cerebellar axons project to multiple compartments with terminals clustered mainly in the conventional spinocerebellar region with a coarse topography, which relates to the cortical compartments defined by aldolase C.
Title: Projection patterns of single mossy fiber axons originating from the dorsal column nuclei mapped on the aldolase C compartments in the rat cerebellar cortex.
The results revealed a tight link between the projection patterns of individual Purkinje cell axons, the topography of the olivocerebellar pathway, and the aldolase C expression pattern.
Title: Projection of reconstructed single Purkinje cell axons in relation to the cortical and nuclear aldolase C compartments of the rat cerebellum.
the aldolase C compartments and olivocerebellar projection are organized according to a common fundamental organization in the mouse and rat
Title: Identification of aldolase C compartments in the mouse cerebellar cortex by olivocerebellar labeling.
A species difference between rat and mouse is found in both mRNA and protein expression of zebrin II/aldolase C in the cerebellum. There also appears to be a transition in expression that occurs in vivo between postnatal days 8 and 10.
Title: Development of cerebellar modules: extrinsic control of late-phase zebrin II pattern and the exploration of rat/mouse species differences.
brain-specific aldolase C gene could constitute a new target for the transcription factor Pax-6, which is implicated increasingly in neurogenesis
Title: Novel target sequences for Pax-6 in the brain-specific activating regions of the rat aldolase C gene.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE096286 (e-PCR)
- UniSTS:244008

D10Wox15 (e-PCR)
- UniSTS:118129

D10Arb9 (e-PCR), detects polymorphism
- UniSTS:226265

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-bisphosphate aldolase activity	IEA Inferred from Electronic Annotation more info
enables fructose-bisphosphate aldolase activity	ISO Inferred from Sequence Orthology more info
enables fructose-bisphosphate aldolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 1,6-bisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose 1,6-bisphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organonitrogen compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fructose-bisphosphate aldolase C

Names: aldolase C, fructose-biphosphate; aldolase C, fructose-bisphosphate; brain-type aldolase

NP_036629.1

EC 4.1.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.