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    Pigt phosphatidylinositol glycan anchor biosynthesis, class T [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296360, updated on 9-May-2024

    Summary

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    Official Symbol
    Pigtprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Tprovided by RGD
    Primary source
    RGD:1307156
    See related
    Ensembl:ENSRNOG00000014690 AllianceGenome:RGD:1307156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in attachment of GPI anchor to protein. Predicted to act upstream of or within neuron apoptotic process and neuron differentiation. Predicted to be located in cytoplasmic vesicle. Predicted to be part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 84.8), Lung (RPKM 67.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pigt in Genome Data Viewer
    Location:
    3q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173647104..173656269)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153227749..153236922)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160945556..160954738)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Sys1 golgi trafficking protein Neighboring gene TP53 target 5 Neighboring gene dysbindin domain containing 2 Neighboring gene uncharacterized LOC120101784 Neighboring gene bolA family member 2, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. Li HL, et al. FEBS Lett, 2006 Mar 20. PMID 16516892
    2. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. Ohishi K, et al. EMBO J, 2001 Aug 1. PMID 11483512, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GPI transamidase component PIG-T
    Names
    phosphatidylinositol glycan, class T

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106540.2 → NP_001100010.2  GPI transamidase component PIG-T isoform 1 precursor

      See identical proteins and their annotated locations for NP_001100010.2

      Status: PROVISIONAL

      Source sequence(s)
      CH474005
      UniProtKB/TrEMBL
      A6JX95, D4A604
      Related
      ENSRNOP00000090741.1, ENSRNOT00000117035.1
      Conserved Domains (1) summary
      pfam04113
      Location:34 → 565
      Gpi16; Gpi16 subunit, GPI transamidase component

    2. NM_001430209.1 → NP_001417138.1  GPI transamidase component PIG-T isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173647104..173656269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235532.5 → XP_006235594.2  GPI transamidase component PIG-T isoform X1

      UniProtKB/TrEMBL
      D4A604
      Related
      ENSRNOP00000019761.7
      Conserved Domains (1) summary
      pfam04113
      Location:34 → 566
      Gpi16; Gpi16 subunit, GPI transamidase component
    Nucleotide Protein Strain
    Heading Accession and Version

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