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    Gin1 gypsy retrotransposon integrase 1 [ Mus musculus (house mouse) ]

    Gene ID: 252876, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Gin1provided by MGI
    Official Full Name
    gypsy retrotransposon integrase 1provided by MGI
    Primary source
    MGI:MGI:2182036
    See related
    Ensembl:ENSMUSG00000026333 AllianceGenome:MGI:2182036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gin-1; Zh2c2; 4930429M06Rik; 8430411H10Rik
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA integration. Orthologous to human GIN1 (gypsy retrotransposon integrase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 2.6), liver E14.5 (RPKM 1.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gin1 in Genome Data Viewer
    Location:
    1 D; 1 47.76 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (97697894..97721435)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (97770172..97793710)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01776 Neighboring gene predicted gene 7135 Neighboring gene STARR-seq mESC enhancer starr_01777 Neighboring gene STARR-seq mESC enhancer starr_01778 Neighboring gene VISTA enhancer mm1317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:99476944-99477212 Neighboring gene STARR-positive B cell enhancer ABC_E3293 Neighboring gene macrophage immunometabolism regulator Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene STARR-seq mESC enhancer starr_01779 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:99666627-99666810 Neighboring gene STARR-seq mESC enhancer starr_01781 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene predicted gene, 31771 Neighboring gene basic transcription factor 3, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mammalian gene evolved from the integrase domain of an LTR retrotransposon. Lloréns C, et al. Mol Biol Evol, 2001 Aug. PMID 11470852
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29171

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gypsy retrotransposon integrase-like protein 1
    Names
    zinc finger H2C2 domain-containing protein
    zinc finger, H2C2 domain containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310773.1 → NP_001297702.1  gypsy retrotransposon integrase-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001297702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC102191, AK014287, AK169361
      Consensus CDS
      CCDS78662.1
      UniProtKB/Swiss-Prot
      Q8K259
      Related
      ENSMUSP00000027571.7, ENSMUST00000027571.13

    2. NM_026250.3 → NP_080526.2  gypsy retrotransposon integrase-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080526.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102191, AK014287, AK169361
      Consensus CDS
      CCDS35679.1
      UniProtKB/Swiss-Prot
      Q3TEY8, Q3V2V3, Q8C3X6, Q8K259, Q9CXB6, Q9D5K2
      Related
      ENSMUSP00000108464.4, ENSMUST00000112844.10
      Conserved Domains (1) summary
      cl07828
      Location:85 → 119
      zf-H2C2; His(2)-Cys(2) zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      97697894..97721435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529614.5 → XP_006529677.1  gypsy retrotransposon integrase-like protein 1 isoform X1

      Conserved Domains (1) summary
      cl21549
      Location:80 → 132
      rve; Integrase core domain

    2. XM_006529616.4 → XP_006529679.1  gypsy retrotransposon integrase-like protein 1 isoform X3

    3. XM_030254329.1 → XP_030110189.1  gypsy retrotransposon integrase-like protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K259.2 GenPept UniProtKB/Swiss-Prot:Q8K259

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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