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    Rnps1 RNA binding protein with serine rich domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287113, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnps1provided by RGD
    Official Full Name
    RNA binding protein with serine rich domain 1provided by RGD
    Primary source
    RGD:1307522
    See related
    Ensembl:ENSRNOG00000008703 AllianceGenome:RGD:1307522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of apoptotic process; and regulation of mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RNPS1 (RNA binding protein with serine rich domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 459.8), Spleen (RPKM 322.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnps1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13950151..13960396)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13445516..13455858)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13786339..13796720)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, subfamily A (ABC1), member 17 Neighboring gene uncharacterized LOC134480760 Neighboring gene ATP binding cassette subfamily A member 3 Neighboring gene uncharacterized LOC120095048 Neighboring gene enoyl-CoA delta isomerase 1 Neighboring gene deoxyribonuclease 1 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ever-increasing complexities of the exon junction complex. Tange TØ, et al. Curr Opin Cell Biol, 2004 Jun. PMID 15145352
    2. ASAP, a novel protein complex involved in RNA processing and apoptosis. Schwerk C, et al. Mol Cell Biol, 2003 Apr. PMID 12665594, Free PMC Article
    3. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Michelle L, et al. Mol Cell Biol, 2012 Mar. PMID 22203037, Free PMC Article
    4. The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Murachelli AG, et al. Nat Struct Mol Biol, 2012 Mar 4. PMID 22388736
    5. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Lykke-Andersen J, et al. Science, 2001 Sep 7. PMID 11546874

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ASAP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ASAP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein with serine-rich domain 1
    Names
    RNA binding protein S1
    ribonucleic acid binding protein S1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011890.1 → NP_001011890.1  RNA-binding protein with serine-rich domain 1

      See identical proteins and their annotated locations for NP_001011890.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079014
      UniProtKB/Swiss-Prot
      Q6AYK1
      UniProtKB/TrEMBL
      A0A8L2QN59, A6HCR9
      Related
      ENSRNOP00000047771.4, ENSRNOT00000010915.6
      Conserved Domains (1) summary
      cd12365
      Location:163 → 236
      RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13950151..13960396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245933.4 → XP_006245995.1  RNA-binding protein with serine-rich domain 1 isoform X1

      See identical proteins and their annotated locations for XP_006245995.1

      UniProtKB/TrEMBL
      A0A8I6AKA2
      Related
      ENSRNOP00000094781.1
      Conserved Domains (1) summary
      cd12365
      Location:140 → 213
      RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYK1.1 GenPept UniProtKB/Swiss-Prot:Q6AYK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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