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    Mrps27 mitochondrial ribosomal protein S27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361883, updated on 1-Apr-2024

    Summary

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    Official Symbol
    Mrps27provided by RGD
    Official Full Name
    mitochondrial ribosomal protein S27provided by RGD
    Primary source
    RGD:1311829
    See related
    Ensembl:ENSRNOG00000017272 AllianceGenome:RGD:1311829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mitochondrial ribosome binding activity; rRNA binding activity; and tRNA binding activity. Predicted to be involved in cell population proliferation and positive regulation of mitochondrial translation. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MRPS27 (mitochondrial ribosomal protein S27). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 92.5), Adrenal (RPKM 83.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrps27 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (32474178..32542741)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (30740007..30808577)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (29598344..29666711)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485827 Neighboring gene zinc finger protein 366 Neighboring gene pentatricopeptide repeat domain 2 Neighboring gene microtubule-associated protein 1B Neighboring gene uncharacterized LOC102553545

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes. Pu M, et al. Tumour Biol, 2017 Jul. PMID 28714366
    2. MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins. Davies SM, et al. FEBS Lett, 2012 Oct 19. PMID 22841715
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mitochondrial ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS27
    Names
    28S ribosomal protein S27, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108543.2 → NP_001102013.1  small ribosomal subunit protein mS27 isoform 2

      See identical proteins and their annotated locations for NP_001102013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and uses a distinct 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K6X0, A6I563
      Related
      ENSRNOP00000073974.1, ENSRNOT00000088580.2
      Conserved Domains (1) summary
      pfam10037
      Location:1 → 94
      MRP-S27; Mitochondrial 28S ribosomal protein S27

    2. NM_001199192.1 → NP_001186121.1  small ribosomal subunit protein mS27 isoform 1

      See identical proteins and their annotated locations for NP_001186121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CB576151, DN934981, FM121157, JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZNY6, A6I559, D4A3E8
      Related
      ENSRNOP00000023286.4, ENSRNOT00000023286.7
      Conserved Domains (2) summary
      sd00004
      Location:111 → 135
      PPR; PPR repeat [structural motif]
      pfam10037
      Location:1 → 406
      MRP-S27; Mitochondrial 28S ribosomal protein S27

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      32474178..32542741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102541.1 → XP_038958469.1  small ribosomal subunit protein mS27 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNY6
      Conserved Domains (1) summary
      pfam10037
      Location:1 → 341
      MRP-S27; Mitochondrial 28S ribosomal protein S27

    2. XM_039102540.1 → XP_038958468.1  small ribosomal subunit protein mS27 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNY6
      Conserved Domains (2) summary
      sd00004
      Location:51 → 75
      PPR; PPR repeat [structural motif]
      pfam10037
      Location:34 → 346
      MRP-S27; Mitochondrial 28S ribosomal protein S27

    3. XM_039102543.2 → XP_038958471.1  small ribosomal subunit protein mS27 isoform X3

      UniProtKB/TrEMBL
      A6I565
      Conserved Domains (1) summary
      pfam10037
      Location:1 → 259
      MRP-S27; Mitochondrial 28S ribosomal protein S27

    4. XM_039102542.2 → XP_038958470.1  small ribosomal subunit protein mS27 isoform X3

      UniProtKB/TrEMBL
      A6I565
      Conserved Domains (1) summary
      pfam10037
      Location:1 → 259
      MRP-S27; Mitochondrial 28S ribosomal protein S27

    5. XM_017590949.2 → XP_017446438.1  small ribosomal subunit protein mS27 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNY6
      Conserved Domains (2) summary
      sd00004
      Location:51 → 75
      PPR; PPR repeat [structural motif]
      pfam10037
      Location:34 → 346
      MRP-S27; Mitochondrial 28S ribosomal protein S27
    Nucleotide Protein Strain
    Heading Accession and Version

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