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    Nudt22 nudix hydrolase 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293703, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Nudt22provided by RGD
    Official Full Name
    nudix hydrolase 22provided by RGD
    Primary source
    RGD:735224
    See related
    Ensembl:ENSRNOG00000021158 AllianceGenome:RGD:735224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP-mannose hydrolase activity; UDP-sugar diphosphatase activity; and metal ion binding activity. Predicted to be located in nucleoplasm. Orthologous to human NUDT22 (nudix hydrolase 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 80.8), Muscle (RPKM 75.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nudt22 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213612008..213615626, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204182797..204186421, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222247500..222251053, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vascular endothelial growth factor B Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene tRNA phosphotransferase 1 Neighboring gene FERM domain containing kindlin 3 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene uncharacterized LOC120099981

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. Carter M, et al. Structure, 2018 Feb 6. PMID 29413322
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72981

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-mannose hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-sugar diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-sugar diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uridine diphosphate glucose pyrophosphatase NUDT22
    Names
    UDPG pyrophosphatase
    UGPPase
    nucleoside diphosphate-linked moiety X motif 22
    nudix (nucleoside diphosphate linked moiety X)-type motif 22
    nudix motif 22
    NP_954521.1
    XP_006230822.1
    XP_038964460.1
    XP_038964462.1
    XP_038964465.1
    XP_063142953.1
    XP_063142954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199090.2 → NP_954521.1  uridine diphosphate glucose pyrophosphatase NUDT22

      See identical proteins and their annotated locations for NP_954521.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060593
      UniProtKB/Swiss-Prot
      Q6P9U1
      UniProtKB/TrEMBL
      A6HZM7
      Related
      ENSRNOP00000028734.3, ENSRNOT00000028734.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213612008..213615626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286883.1 → XP_063142953.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2

      UniProtKB/TrEMBL
      A6HZM6

    2. XM_006230760.5 → XP_006230822.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X1

      See identical proteins and their annotated locations for XP_006230822.1

      UniProtKB/Swiss-Prot
      Q6P9U1
      UniProtKB/TrEMBL
      A6HZM7

    3. XM_039108532.2 → XP_038964460.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9U1
      UniProtKB/TrEMBL
      A6HZM7

    4. XM_039108537.2 → XP_038964465.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2

      UniProtKB/TrEMBL
      A6HZM6

    5. XM_063286884.1 → XP_063142954.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2

      UniProtKB/TrEMBL
      A6HZM6

    6. XM_039108534.2 → XP_038964462.1  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9U1
      UniProtKB/TrEMBL
      A6HZM7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9U1.1 GenPept UniProtKB/Swiss-Prot:Q6P9U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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