Vdac1 voltage-dependent anion channel 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vdac1provided by RGD
Official Full Name: voltage-dependent anion channel 1provided by RGD
Primary source: RGD:621575
See related: Ensembl:ENSRNOG00000006375 AllianceGenome:RGD:621575
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables voltage-gated anion channel activity. Involved in mitochondrial calcium ion transmembrane transport. Located in mitochondrial outer membrane and synaptic vesicle. Part of protein-containing complex. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human VDAC1 (voltage dependent anion channel 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 4256.8), Heart (RPKM 3059.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (37029377..37060542)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (36532306..36559642)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (37724915..37752827)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
Title: UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death.
Inhibition of VDAC1 Rescues Abeta 1-42-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/beta-Catenin Pathways.
Title: Inhibition of VDAC1 Rescues Aβ (1-42)-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β-Catenin Pathways.
VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway.
Title: VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway.
VDAC1 promotes cardiomyocyte autophagy in anoxia/reoxygenation injury via the PINK1/Parkin pathway.
Title: VDAC1 promotes cardiomyocyte autophagy in anoxia/reoxygenation injury via the PINK1/Parkin pathway.
VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism.
Title: VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism.
Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress.
Title: Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress.
MiR-183-5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1.
Title: MiR-183-5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1.
VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury.
Title: VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury.
Authors demonstrated that hydrogen-rich saline (HRS) reduced OGD/RP-mediated neuronal loss by stimulating the expression of Bcl-2, which suppressed the activity of VDAC1.
Title: Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis through VDAC1 via Bcl-2.
Taken together, peroxynitrite produced during cardiac ischemia and reperfusion injury can nitrate tyrosine residues of two key mitochondrial membrane proteins involved in bioenergetics and energy transfer via binding to hexokinase 2 to contribute to mitochondrial and cellular dysfunction.
Title: Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137996 (e-PCR)
- UniSTS:220083

U30840 (e-PCR)
- UniSTS:180190

MARC_23885-23886:1031761371:1 (e-PCR)
- UniSTS:268790

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	TAS Traceable Author Statement more info
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxysterol binding	IEA Inferred from Electronic Annotation more info
enables oxysterol binding	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables porin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic anion channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral fear response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in neuron-neuron synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron-neuron synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
part_of mitochondrial permeability transition pore complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial permeability transition pore complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of pore complex	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: voltage-dependent anion-selective channel protein 1

Names: VDAC-1; outer mitochondrial membrane protein porin 1; rVDAC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031353.3 → NP_112643.1 voltage-dependent anion-selective channel protein 1

See identical proteins and their annotated locations for NP_112643.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

A1L125, Q3MHT8, Q5M944, Q5M972, Q6IN28, Q6P9W9, Q9Z2L0

UniProtKB/TrEMBL

A0A8I6GGP1, A6HEA9

Related

ENSRNOP00000008477.4, ENSRNOT00000008477.6

Conserved Domains (1) summary

cd07306
Location:4 → 282

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

37029377..37060542

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269962.1 → XP_063126032.1 voltage-dependent anion-selective channel protein 1 isoform X2
XM_063269961.1 → XP_063126031.1 voltage-dependent anion-selective channel protein 1 isoform X1