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    Adcy4 adenylate cyclase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54223, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Adcy4provided by RGD
    Official Full Name
    adenylate cyclase 4provided by RGD
    Primary source
    RGD:2034
    See related
    Ensembl:ENSRNOG00000020401 AllianceGenome:RGD:2034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables G-protein beta/gamma-subunit complex binding activity and adenylate cyclase activity. Involved in cAMP biosynthetic process and intracellular signal transduction. Located in membrane and nucleus. Part of protein-containing complex. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 76.9), Lung (RPKM 53.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adcy4 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33236201..33252070, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29266280..29282153, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34453917..34469779, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor Neighboring gene receptor-interacting serine-threonine kinase 3 Neighboring gene nuclear factor of activated T-cells 4 Neighboring gene NYN domain and retroviral integrase containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distribution of adenylyl cyclases in the rat ovary by immunofluorescence microscopy. Bagavandoss P, et al. Anat Rec (Hoboken), 2012 Oct. PMID 22899545
    2. Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunits. Zimmermann G, et al. J Biol Chem, 1996 Oct 25. PMID 8900209
    3. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Gao BN, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946437, Free PMC Article
    4. Regulation and immunohistochemical localization of betagamma-stimulated adenylyl cyclases in mouse hippocampus. Baker LP, et al. J Neurosci, 1999 Jan 1. PMID 9870949, Free PMC Article
    5. Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein. Wang HY, et al. J Neurobiol, 2006 Oct. PMID 16967511

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93493

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylate cyclase type 4
    Names
    ATP pyrophosphate-lyase 4
    adenylate cyclase type IV
    adenylyl cyclase 4
    NP_062158.2
    XP_038949538.1
    XP_038949539.1
    XP_063130658.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019285.2 → NP_062158.2  adenylate cyclase type 4

      See identical proteins and their annotated locations for NP_062158.2

      Status: VALIDATED

      Source sequence(s)
      BC081813
      UniProtKB/Swiss-Prot
      P26770
      UniProtKB/TrEMBL
      A6KH53, F7EY48, Q66HK5
      Related
      ENSRNOP00000027719.4, ENSRNOT00000027719.8
      Conserved Domains (4) summary
      smart00044
      Location:219 → 422
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:861 → 1060
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:479 → 580
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:115 → 246
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33236201..33252070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093610.1 → XP_038949538.1  adenylate cyclase type 4 isoform X1

      UniProtKB/Swiss-Prot
      P26770
      Conserved Domains (3) summary
      pfam00211
      Location:729 → 928
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:1 → 114
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:347 → 448
      DUF1053; Domain of Unknown Function (DUF1053)

    2. XM_039093611.1 → XP_038949539.1  adenylate cyclase type 4 isoform X3

      Conserved Domains (3) summary
      pfam00211
      Location:547 → 746
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:165 → 266
      DUF1053; Domain of Unknown Function (DUF1053)
      cl11967
      Location:2 → 116
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    3. XM_063274588.1 → XP_063130658.1  adenylate cyclase type 4 isoform X2

      UniProtKB/TrEMBL
      A6KH55
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26770.1 GenPept UniProtKB/Swiss-Prot:P26770

    Gene LinkOut

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