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    Pum3 pumilio RNA-binding family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499339, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Pum3provided by RGD
    Official Full Name
    pumilio RNA-binding family member 3provided by RGD
    Primary source
    RGD:1564753
    See related
    Ensembl:ENSRNOG00000012574 AllianceGenome:RGD:1564753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of protein ADP-ribosylation and regulation of translation. Predicted to be located in chromosome; endoplasmic reticulum; and nucleoplasm. Predicted to be active in nucleolus. Orthologous to human PUM3 (pumilio RNA binding family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 62.4), Adrenal (RPKM 57.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pum3 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (234483482..234527718, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (225074332..225113995, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (245476400..245517081, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100010 Neighboring gene uncharacterized LOC134485215 Neighboring gene very low density lipoprotein receptor Neighboring gene potassium voltage-gated channel modifier subfamily V member 2 Neighboring gene uncharacterized LOC102555808 Neighboring gene uncharacterized LOC102555989 Neighboring gene uncharacterized LOC134485216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress. Chang HY, et al. Cancer Res, 2011 Feb 1. PMID 21266351
    2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
    3. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pumilio homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025036.1 → NP_001020207.1  pumilio homolog 3

      See identical proteins and their annotated locations for NP_001020207.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092579
      UniProtKB/Swiss-Prot
      Q4G054, Q562C7
      UniProtKB/TrEMBL
      A0A8L2QIX0
      Related
      ENSRNOP00000034834.4, ENSRNOT00000033724.5
      Conserved Domains (2) summary
      cl21719
      Location:181 → 441
      Pumilio; Pumilio-family RNA binding domain
      pfam08144
      Location:433 → 570
      CPL; CPL (NUC119) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      234483482..234527718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271704.1 → XP_063127774.1  pumilio homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QIX0

    2. XM_063271710.1 → XP_063127780.1  pumilio homolog 3 isoform X2

      UniProtKB/Swiss-Prot
      Q4G054, Q562C7
      UniProtKB/TrEMBL
      A0A8L2QIX0

    3. XM_063271708.1 → XP_063127778.1  pumilio homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QIX0

    4. XM_063271714.1 → XP_063127784.1  pumilio homolog 3 isoform X2

      UniProtKB/Swiss-Prot
      Q4G054, Q562C7
      UniProtKB/TrEMBL
      A0A8L2QIX0

    5. XM_063271722.1 → XP_063127792.1  pumilio homolog 3 isoform X4

      UniProtKB/TrEMBL
      A6I0T5

    6. XM_063271726.1 → XP_063127796.1  pumilio homolog 3 isoform X5

    7. XM_063271719.1 → XP_063127789.1  pumilio homolog 3 isoform X3

    RNA

    1. XR_010056425.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q562C7.1 GenPept UniProtKB/Swiss-Prot:Q562C7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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