Cthrc1 collagen triple helix repeat containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cthrc1provided by RGD
Official Full Name: collagen triple helix repeat containing 1provided by RGD
Primary source: RGD:628801
See related: Ensembl:ENSRNOG00000004578 AllianceGenome:RGD:628801
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Wnt-protein binding activity and frizzled binding activity. Acts upstream of or within cell migration. Located in extracellular matrix. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human CTHRC1 (collagen triple helix repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 46.1), Muscle (RPKM 36.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (72007372..72017654)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (70122474..70132756)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (77966722..77977004)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cthrc1 has role in bladder growth following denervation.
Title: Array profiling reveals contribution of Cthrc1 to growth of the denervated rat urinary bladder.
CTHRC1 downregulation suppresses IL-1beta-induced JNK1/2 activation.
Title: CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling.
Overexpression of CHTRC1 increased osteogenic differentiation of periodontal ligament stem cells, which could be abolished by TAZ siRNA.
Title: CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ.
Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen levels with potentially broad implications for cell metabolism and physiology.
Title: Cthrc1, a novel circulating hormone regulating metabolism.
Intracellular localization of Cthrc1 characterizes differentiated smooth muscle.
Title: Intracellular localization of Cthrc1 characterizes differentiated smooth muscle.
CTHRC1 is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration.
Title: Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration.
Cthrc1 is a cell-type-specific inhibitor of transforming growth factor-beta, which in turn impacts collagen type I and III deposition, neointimal formation, and dedifferentiation of smooth muscle cells.
Title: Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway, planar cell polarity pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cochlea morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of planar polarity involved in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of planar polarity involved in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in inner ear receptor cell stereocilium organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ossification involved in bone remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification involved in bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	IEA Inferred from Electronic Annotation more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: collagen triple helix repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271300.1 → NP_001258229.1 collagen triple helix repeat-containing protein 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2Q207, A6HR68

Conserved Domains (1) summary

pfam01391
Location:44 → 76

Collagen; Collagen triple helix repeat (20 copies)
NM_172333.2 → NP_758836.1 collagen triple helix repeat-containing protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_758836.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q8CG08

UniProtKB/TrEMBL

A0A8L2Q207, A6HR68

Related

ENSRNOP00000006142.3, ENSRNOT00000006142.4

Conserved Domains (1) summary

pfam01391
Location:59 → 91

Collagen; Collagen triple helix repeat (20 copies)