Col1a1 collagen type I alpha 1 chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Col1a1provided by RGD
Official Full Name: collagen type I alpha 1 chainprovided by RGD
Primary source: RGD:61817
See related: Ensembl:ENSRNOG00000003897 AllianceGenome:RGD:61817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: COLIA1
Summary: Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mechanical stimulus; and cellular response to retinoic acid. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and secretory granule. Used to study cholestasis and non-alcoholic fatty liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 2843.4), Uterus (RPKM 1554.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80380458..80397461)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79883622..79900625)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82745801..82762790)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COL1A1 as a potential new biomarker and therapeutic target for type 2 diabetes.
Title: COL1A1 as a potential new biomarker and therapeutic target for type 2 diabetes.
Expression of Metalloproteinases and Type I and III Collagens during Healing of Excisional Skin Wound on the Abdomen and Back in Rats.
Title: Expression of Metalloproteinases and Type I and III Collagens during Healing of Excisional Skin Wound on the Abdomen and Back in Rats.
the collagen1a1 promoter is tightly regulated and pro-remodeling factors produce an overall net effect on collagen expression, rather than additive
Title: Pro-remodeling peptides modulate collagen α1(I) promoter activity in rat cardiac myofibroblasts.
differential collagen degradation by MT1-MMP induced a structural disorganization of adult collagen and inhibits DDR1 activation.
Title: Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells.
the activation of Pin1 promoted cardiac extracellular matrix deposition and oxidative stress damage by regulating the phosphorylation of the MEK1/2ERK1/2 signaling pathway and the expression of alphaSMA.
Title: Pin1 facilitates isoproterenol‑induced cardiac fibrosis and collagen deposition by promoting oxidative stress and activating the MEK1/2‑ERK1/2 signal transduction pathway in rats.
In vitro analysis using LX2 HSC cells indicated that ATII can augment TGFbeta1 and collagen type I alpha1 mRNA expression via periostin expression, suggesting that the interaction between ATII and periostin may serve a role in liver fibrosis development. In conclusion, blockade of ATIIinduced periostin may suppress the progression of liver fibrosis development.
Title: Periostin cross‑reacts with the renin‑angiotensin system during liver fibrosis development.
miR21 regulates expression of alphaSMA and collagen I in activated rat hepatic stellate cells by directly targeting Smad7.
Title: miR‑21 promotes α‑SMA and collagen I expression in hepatic stellate cells via the Smad7 signaling pathway.
Taken together, the lentiviral RNAi vector targeting the TGF beta-1 gene of rats was successfully constructed, which effectively silenced the TGF beta-1 gene of the HSCT6 cells and inhibited the expression of Col1a1.
Title: Effects of lentiviral vector‑mediated shRNA silencing of TGFβ1 on the expression of Col1a1 in rat hepatic stellate cells.
the diagnostic value of urinary collagen degradation products in a proteinuria-driven fibrosis rat model, was investigated.
Title: Urinary collagen degradation products as early markers of progressive renal fibrosis.
Brefeldin A induced a significant up-regulation of Col1a1 mRNA levels in CFSC-2G hepatic stellate cells that was time-dependent. The UPR correlated with enhanced mRNA and protein levels of collagen type I in these cells. Analysis of the 3 branches of UPR revealed the activation of IRE1alpha, PERK and ATF6 in response to BFA. An IRE1alpha-p38 MAPK-Smad pathway may be responsible for the fibrogenic action of BFA on HSC.
Title: Unfolded protein response induced by Brefeldin A increases collagen type I levels in hepatic stellate cells through an IRE1α, p38 MAPK and Smad-dependent pathway.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC275467P3 (e-PCR)
- UniSTS:272384

COL1A1 (e-PCR)
- UniSTS:504624

PMC34669P1 (e-PCR)
- UniSTS:273227

PMC151926P1 (e-PCR)
- UniSTS:271192

RH128280 (e-PCR)
- UniSTS:211588

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone trabecula formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fluoride	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within face morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intramembranous ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in ossification	IBA Inferred from Biological aspect of Ancestor more info
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fluoride	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in skin development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in skin morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in tooth mineralization	ISO Inferred from Sequence Orthology more info
involved_in visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	ISO Inferred from Sequence Orthology more info
part_of collagen type I trimer	IBA Inferred from Biological aspect of Ancestor more info
part_of collagen type I trimer	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: collagen alpha-1(I) chain

Names: alpha-1 type I collagen; collagen, type 1, alpha 1; collagen, type I, alpha 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; type I-alpha 1 collagen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053304.1 → NP_445756.1 collagen alpha-1(I) chain precursor

See identical proteins and their annotated locations for NP_445756.1

Status: VALIDATED

Source sequence(s)

BC133728, BQ206338, CB579389, CB693258, CO397981

UniProtKB/Swiss-Prot

A3KNA1, P02454, P02455, Q63079

Related

ENSRNOP00000005311.5, ENSRNOT00000005311.7

Conserved Domains (3) summary

pfam01391
Location:225 → 284

Collagen; Collagen triple helix repeat (20 copies)

smart00214
Location:31 → 86

VWC; von Willebrand factor (vWF) type C domain

pfam01410
Location:1219 → 1452

COLFI; Fibrillar collagen C-terminal domain