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    Tacc2 transforming, acidic coiled-coil containing protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309025, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tacc2provided by RGD
    Official Full Name
    transforming, acidic coiled-coil containing protein 2provided by RGD
    Primary source
    RGD:1303004
    See related
    Ensembl:ENSRNOG00000020457 AllianceGenome:RGD:1303004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Muscle (RPKM 319.1), Heart (RPKM 196.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q37
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194546428..194758152)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185139223..185327881)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201140264..201329612)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 1700022C21 Neighboring gene uncharacterized LOC134483930 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene transfer RNA proline (anticodon AGG) 25 Neighboring gene uncharacterized LOC103691241 Neighboring gene uncharacterized LOC134483936 Neighboring gene BTB domain containing 16 Neighboring gene pleckstrin homology domain containing A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of an evolutionarily conserved splice variant in the rat Tacc2 gene. Padhi BK, et al. Genesis, 2014 May. PMID 24700488
    2. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Xie Z, et al. Neuron, 2007 Oct 4. PMID 17920017, Free PMC Article
    3. Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. Still IH, et al. BMC Evol Biol, 2004 Jun 18. PMID 15207008, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within interkinetic nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 2
    Names
    transforming acidic coiled coil 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004415.3 → NP_001004415.1  transforming acidic coiled-coil-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), also called the long form, represents the longer transcript.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZXK3
      Related
      ENSRNOP00000051820.3, ENSRNOT00000054937.6
      Conserved Domains (3) summary
      pfam05010
      Location:2628 → 2828
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:2739 → 2827
      FadA; Adhesion protein FadA
      cl23765
      Location:2647 → 2764
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_001004418.3 → NP_001004418.1  transforming acidic coiled-coil-containing protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), also called the short form, lacks an in-frame exon in the coding region, compared to variant 1. Variant 2 encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4A858
      Related
      ENSRNOP00000042296.3, ENSRNOT00000047161.5
      Conserved Domains (3) summary
      pfam05010
      Location:923 → 1123
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:1034 → 1122
      FadA; Adhesion protein FadA
      cl23765
      Location:942 → 1044
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. NM_001415936.1 → NP_001402865.1  transforming acidic coiled-coil-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      X4YHC6

    4. NM_001415937.1 → NP_001402866.1  transforming acidic coiled-coil-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000077927.1, ENSRNOT00000119746.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      194546428..194758152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263499.1 → XP_063119569.1  transforming acidic coiled-coil-containing protein 2 isoform X12

    2. XM_063263527.1 → XP_063119597.1  transforming acidic coiled-coil-containing protein 2 isoform X19

    3. XM_063263507.1 → XP_063119577.1  transforming acidic coiled-coil-containing protein 2 isoform X15

    4. XM_063263532.1 → XP_063119602.1  transforming acidic coiled-coil-containing protein 2 isoform X20

    5. XM_063263562.1 → XP_063119632.1  transforming acidic coiled-coil-containing protein 2 isoform X27

    6. XM_063263617.1 → XP_063119687.1  transforming acidic coiled-coil-containing protein 2 isoform X42

    7. XM_063263519.1 → XP_063119589.1  transforming acidic coiled-coil-containing protein 2 isoform X18

    8. XM_063263502.1 → XP_063119572.1  transforming acidic coiled-coil-containing protein 2 isoform X13

    9. XM_063263469.1 → XP_063119539.1  transforming acidic coiled-coil-containing protein 2 isoform X3

    10. XM_063263487.1 → XP_063119557.1  transforming acidic coiled-coil-containing protein 2 isoform X9

    11. XM_063263471.1 → XP_063119541.1  transforming acidic coiled-coil-containing protein 2 isoform X4

    12. XM_063263480.1 → XP_063119550.1  transforming acidic coiled-coil-containing protein 2 isoform X7

    13. XM_063263505.1 → XP_063119575.1  transforming acidic coiled-coil-containing protein 2 isoform X14

    14. XM_063263464.1 → XP_063119534.1  transforming acidic coiled-coil-containing protein 2 isoform X1

    15. XM_039078550.2 → XP_038934478.2  transforming acidic coiled-coil-containing protein 2 isoform X11

    16. XM_063263476.1 → XP_063119546.1  transforming acidic coiled-coil-containing protein 2 isoform X6

    17. XM_063263484.1 → XP_063119554.1  transforming acidic coiled-coil-containing protein 2 isoform X8

    18. XM_063263513.1 → XP_063119583.1  transforming acidic coiled-coil-containing protein 2 isoform X16

    19. XM_063263466.1 → XP_063119536.1  transforming acidic coiled-coil-containing protein 2 isoform X2

    20. XM_063263488.1 → XP_063119558.1  transforming acidic coiled-coil-containing protein 2 isoform X10

    21. XM_063263516.1 → XP_063119586.1  transforming acidic coiled-coil-containing protein 2 isoform X17

    22. XM_063263474.1 → XP_063119544.1  transforming acidic coiled-coil-containing protein 2 isoform X5

    23. XM_063263613.1 → XP_063119683.1  transforming acidic coiled-coil-containing protein 2 isoform X41

    24. XM_063263565.1 → XP_063119635.1  transforming acidic coiled-coil-containing protein 2 isoform X28

    25. XM_063263592.1 → XP_063119662.1  transforming acidic coiled-coil-containing protein 2 isoform X35

    26. XM_063263607.1 → XP_063119677.1  transforming acidic coiled-coil-containing protein 2 isoform X39

      UniProtKB/TrEMBL
      A0A8I5XWM5

    27. XM_063263611.1 → XP_063119681.1  transforming acidic coiled-coil-containing protein 2 isoform X40

      UniProtKB/TrEMBL
      A0A8I6AEP2

    28. XM_063263612.1 → XP_063119682.1  transforming acidic coiled-coil-containing protein 2 isoform X39

      UniProtKB/TrEMBL
      A0A8I5XWM5

    29. XM_063263555.1 → XP_063119625.1  transforming acidic coiled-coil-containing protein 2 isoform X24

    30. XM_063263543.1 → XP_063119613.1  transforming acidic coiled-coil-containing protein 2 isoform X22

    31. XM_017589222.3 → XP_017444711.1  transforming acidic coiled-coil-containing protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A0G2JTE3, D4A858
      Related
      ENSRNOP00000068677.2

    32. XM_017589223.3 → XP_017444712.1  transforming acidic coiled-coil-containing protein 2 isoform X30

      UniProtKB/TrEMBL
      D4A858

    33. XM_063263589.1 → XP_063119659.1  transforming acidic coiled-coil-containing protein 2 isoform X33

    34. XM_063263606.1 → XP_063119676.1  transforming acidic coiled-coil-containing protein 2 isoform X38

    35. XM_063263560.1 → XP_063119630.1  transforming acidic coiled-coil-containing protein 2 isoform X26

    36. XM_063263550.1 → XP_063119620.1  transforming acidic coiled-coil-containing protein 2 isoform X23

    37. XM_008759883.4 → XP_008758105.1  transforming acidic coiled-coil-containing protein 2 isoform X32

      UniProtKB/TrEMBL
      D4A858
      Conserved Domains (3) summary
      pfam05010
      Location:785 → 985
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:896 → 984
      FadA; Adhesion protein FadA
      cl11495
      Location:788 → 912
      IncFII_repA; IncFII RepA protein family

    38. XM_063263591.1 → XP_063119661.1  transforming acidic coiled-coil-containing protein 2 isoform X34

    39. XM_039078566.2 → XP_038934494.1  transforming acidic coiled-coil-containing protein 2 isoform X37

      UniProtKB/TrEMBL
      A6IA38
      Conserved Domains (2) summary
      PRK13335
      Location:181 → 292
      PRK13335; superantigen-like protein SSL3; Reviewed
      pfam05010
      Location:738 → 938
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    40. XM_063263597.1 → XP_063119667.1  transforming acidic coiled-coil-containing protein 2 isoform X36

    41. XM_063263569.1 → XP_063119639.1  transforming acidic coiled-coil-containing protein 2 isoform X29

    42. XM_063263537.1 → XP_063119607.1  transforming acidic coiled-coil-containing protein 2 isoform X21

    43. XM_063263577.1 → XP_063119647.1  transforming acidic coiled-coil-containing protein 2 isoform X31

    Nucleotide Protein Strain
    Heading Accession and Version

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