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    TDRD10 tudor domain containing 10 [ Homo sapiens (human) ]

    Gene ID: 126668, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TDRD10provided by HGNC
    Official Full Name
    tudor domain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:25316
    See related
    Ensembl:ENSG00000163239 AllianceGenome:HGNC:25316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 14.5), lung (RPKM 1.6) and 2 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    1q21.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154502219..154548147)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153639357..153685274)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154474695..154520623)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154378343-154378949 Neighboring gene IL6R antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154390689-154391202 Neighboring gene interleukin 6 receptor Neighboring gene proteasome 26S subunit, non-ATPase, 8 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154399170-154399670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154399671-154400171 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154404493-154405326 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154405327-154406158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154406159-154406992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154417761-154418260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154437441-154437942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154461067-154461569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154461570-154462071 Neighboring gene Src homology 2 domain containing E Neighboring gene Sharpr-MPRA regulatory region 5559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1779 Neighboring gene UBE2Q1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154530992-154531573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154531574-154532154 Neighboring gene ubiquitin conjugating enzyme E2 Q1 Neighboring gene uncharacterized LOC107985206

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients. Galora S, et al. J Vasc Surg, 2015 Mar. PMID 24423473
    2. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Kauwe JS, et al. PLoS Genet, 2014 Oct. PMID 25340798, Free PMC Article
    3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
    5. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann K, et al. Oncogene, 2019 Apr. PMID 30575818, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest rs6674171 TDRD10 SNP is not a susceptibility factor for abdominal aortic aneurysms in an Italian population.
      Title: Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp434M202

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tudor domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098475.2 → NP_001091945.1  tudor domain-containing protein 10 isoform a

      See identical proteins and their annotated locations for NP_001091945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL162591, AL592078
      Consensus CDS
      CCDS41406.1
      UniProtKB/Swiss-Prot
      A4FU09, B0QZ53, B4DXV4, Q3ZCP1, Q3ZCS7, Q5SXY7, Q5VZ19, Q6UXV2, Q8TCN3
      Related
      ENSP00000357465.3, ENST00000368480.3
      Conserved Domains (3) summary
      COG0724
      Location:8 → 103
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:36 → 103
      RRM_SF; RNA recognition motif (RRM) superfamily
      pfam00567
      Location:219 → 315
      TUDOR; Tudor domain

    2. NM_182499.4 → NP_872305.3  tudor domain-containing protein 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL162591, AL592078
      Consensus CDS
      CCDS30878.2
      UniProtKB/Swiss-Prot
      Q5VZ19
      Related
      ENSP00000357467.4, ENST00000368482.8
      Conserved Domains (3) summary
      COG0724
      Location:8 → 103
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:36 → 103
      RRM_SF; RNA recognition motif (RRM) superfamily
      pfam00567
      Location:219 → 315
      TUDOR; Tudor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      154502219..154548147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509152.3 → XP_011507454.1  tudor domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_011507454.1

      Conserved Domains (3) summary
      COG0724
      Location:7 → 135
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:251 → 347
      TUDOR; Tudor domain
      cl17169
      Location:77 → 134
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_011509153.3 → XP_011507455.1  tudor domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_011507455.1

      Conserved Domains (3) summary
      COG0724
      Location:7 → 135
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:251 → 347
      TUDOR; Tudor domain
      cl17169
      Location:77 → 134
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_011509155.3 → XP_011507457.1  tudor domain-containing protein 10 isoform X3

      Conserved Domains (3) summary
      COG0724
      Location:7 → 135
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:251 → 347
      TUDOR; Tudor domain
      cl17169
      Location:77 → 134
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_011509156.3 → XP_011507458.1  tudor domain-containing protein 10 isoform X4

      Conserved Domains (3) summary
      COG0724
      Location:7 → 110
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:43 → 110
      RRM_SF; RNA recognition motif (RRM) superfamily
      pfam00567
      Location:226 → 322
      TUDOR; Tudor domain

    5. XM_011509157.3 → XP_011507459.1  tudor domain-containing protein 10 isoform X5

      Conserved Domains (3) summary
      COG0724
      Location:7 → 110
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:43 → 110
      RRM_SF; RNA recognition motif (RRM) superfamily
      pfam00567
      Location:226 → 322
      TUDOR; Tudor domain

    6. XM_011509154.3 → XP_011507456.1  tudor domain-containing protein 10 isoform X2

      Conserved Domains (3) summary
      COG0724
      Location:8 → 128
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam00567
      Location:244 → 340
      TUDOR; Tudor domain
      cl17169
      Location:70 → 127
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_047444646.1 → XP_047300602.1  tudor domain-containing protein 10 isoform X11

    8. XM_011509159.4 → XP_011507461.1  tudor domain-containing protein 10 isoform X7

      Conserved Domains (1) summary
      pfam00567
      Location:170 → 266
      TUDOR; Tudor domain

    9. XM_011509158.2 → XP_011507460.1  tudor domain-containing protein 10 isoform X6

      Conserved Domains (1) summary
      pfam00567
      Location:181 → 277
      TUDOR; Tudor domain

    10. XM_011509161.1 → XP_011507463.1  tudor domain-containing protein 10 isoform X9

      See identical proteins and their annotated locations for XP_011507463.1

      UniProtKB/Swiss-Prot
      Q5VZ19
      Conserved Domains (1) summary
      pfam00567
      Location:53 → 149
      TUDOR; Tudor domain

    11. XM_047444641.1 → XP_047300597.1  tudor domain-containing protein 10 isoform X10

    12. XM_017000255.1 → XP_016855744.1  tudor domain-containing protein 10 isoform X8

    13. XM_011509160.2 → XP_011507462.1  tudor domain-containing protein 10 isoform X9

      See identical proteins and their annotated locations for XP_011507462.1

      UniProtKB/Swiss-Prot
      Q5VZ19
      Conserved Domains (1) summary
      pfam00567
      Location:53 → 149
      TUDOR; Tudor domain

    RNA

    1. XR_007076385.1 RNA Sequence

    2. XR_007076384.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      153639357..153685274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334231.1 → XP_054190206.1  tudor domain-containing protein 10 isoform X1

    2. XM_054334232.1 → XP_054190207.1  tudor domain-containing protein 10 isoform X1

    3. XM_054334234.1 → XP_054190209.1  tudor domain-containing protein 10 isoform X3

    4. XM_054334235.1 → XP_054190210.1  tudor domain-containing protein 10 isoform X4

    5. XM_054334236.1 → XP_054190211.1  tudor domain-containing protein 10 isoform X5

    6. XM_054334233.1 → XP_054190208.1  tudor domain-containing protein 10 isoform X2

    7. XM_054334243.1 → XP_054190218.1  tudor domain-containing protein 10 isoform X12

    8. XM_054334238.1 → XP_054190213.1  tudor domain-containing protein 10 isoform X7

    9. XM_054334237.1 → XP_054190212.1  tudor domain-containing protein 10 isoform X6

    10. XM_054334242.1 → XP_054190217.1  tudor domain-containing protein 10 isoform X9

    11. XM_054334244.1 → XP_054190219.1  tudor domain-containing protein 10 isoform X10

    12. XM_054334239.1 → XP_054190214.1  tudor domain-containing protein 10 isoform X8

    13. XM_054334241.1 → XP_054190216.1  tudor domain-containing protein 10 isoform X9

    14. XM_054334240.1 → XP_054190215.1  tudor domain-containing protein 10 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VZ19.3 GenPept UniProtKB/Swiss-Prot:Q5VZ19

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