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    Fn3k fructosamine 3 kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498034, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fn3kprovided by RGD
    Official Full Name
    fructosamine 3 kinaseprovided by RGD
    Primary source
    RGD:1559983
    See related
    Ensembl:ENSRNOG00000036659 AllianceGenome:RGD:1559983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fnsk
    Summary
    Predicted to enable protein-fructosamine 3-kinase activity. Predicted to be involved in epithelial cell differentiation; fructosamine metabolic process; and protein deglycation. Orthologous to human FN3K (fructosamine 3 kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 102.9), Brain (RPKM 97.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fn3k in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (107198566..107214176)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106700670..106715903)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110626462..110642262)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Rab40b, member RAS oncogene family Neighboring gene fructosamine-3-kinase-related protein Neighboring gene tubulin folding cofactor D Neighboring gene zinc finger protein 750 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased protein glycation in fructosamine 3-kinase-deficient mice. Veiga da-Cunha M, et al. Biochem J, 2006 Oct 15. PMID 16819943, Free PMC Article
    2. Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes. Delpierre G, et al. Biochem J, 2002 Aug 1. PMID 11975663, Free PMC Article
    3. Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. Szwergold BS, et al. Diabetes, 2001 Sep. PMID 11522682
    4. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Sanghvi VR, et al. Cell, 2019 Aug 8. PMID 31398338, Free PMC Article
    5. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. Delplanque J, et al. J Biol Chem, 2004 Nov 5. PMID 15331600

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate [FN3K, FN3K-RP]
      Title: Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-fructosamine 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-ribulosamine 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fructosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fructosamine-3-kinase
    NP_001102521.2
    XP_038942579.1
    XP_038942580.1
    XP_063125743.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109051.2 → NP_001102521.2  fructosamine-3-kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZZU8
      Related
      ENSRNOP00000051798.4, ENSRNOT00000054915.5
      Conserved Domains (1) summary
      cl21453
      Location:21 → 309
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      107198566..107214176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086651.2 → XP_038942579.1  fructosamine-3-kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I6AW19
      Related
      ENSRNOP00000097152.1
      Conserved Domains (1) summary
      cl21453
      Location:3 → 165
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039086652.2 → XP_038942580.1  fructosamine-3-kinase isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:3 → 163
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063269673.1 → XP_063125743.1  fructosamine-3-kinase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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