Casq1 calsequestrin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Casq1provided by RGD
Official Full Name: calsequestrin 1provided by RGD
Primary source: RGD:1586677
See related: Ensembl:ENSRNOG00000006930 AllianceGenome:RGD:1586677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium ion binding activity. Involved in several processes, including regulation of sequestering of calcium ion; response to denervation involved in regulation of muscle adaptation; and skeletal muscle tissue development. Located in I band; T-tubule; and terminal cisterna lumen. Colocalizes with Golgi apparatus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CASQ1 (calsequestrin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 14187.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87203021..87212710, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84670648..84680339, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90592676..90602365, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN.
Title: Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN.
CSQ-1 expression in platelets is gradually downregulated as diabetes progresses, causing a progressive disruption of internal Ca2+ store recycling, and platelet function.
Title: Altered platelet calsequestrin abundance, Na⁺/Ca²⁺ exchange and Ca²⁺ signaling responses with the progression of diabetes mellitus.
In EDL muscle, CSQ1 provides a large total pool of releasable Ca2+ in the SR whilst maintaining free [Ca2+] in the SR at sufficiently low levels that Ca2+ leakage through the high density of SERCA1 pumps does not metabolically compromise muscle function.
Title: Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat.

Submit: New GeneRIF Correction

General gene information

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Markers

G64925 (e-PCR)
- UniSTS:225846

RH133764 (e-PCR)
- UniSTS:217047

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein polymerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in regulation of sequestering of calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in regulation of store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to denervation involved in regulation of muscle adaptation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to muscle inactivity	IEP Inferred from Expression Pattern more info	PubMed
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in terminal cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in terminal cisterna lumen	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calsequestrin-1

Names: Aspartactin; Laminin-binding protein; calsequestrin 1 (fast-twitch, skeletal muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159594.1 → NP_001153066.1 calsequestrin-1 precursor

See identical proteins and their annotated locations for NP_001153066.1

Status: VALIDATED

Source sequence(s)

BE109529, CA334109, CB699232, FM056035

UniProtKB/Swiss-Prot

P19633

UniProtKB/TrEMBL

A6JG37

Related

ENSRNOP00000009344.5, ENSRNOT00000009344.7

Conserved Domains (4) summary

cd03065
Location:39 → 158

PDI_b_Calsequestrin_N; PDIb family, Calsequestrin subfamily, N-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...

cd03066
Location:160 → 261

PDI_b_Calsequestrin_middle; PDIb family, Calsequestrin subfamily, Middle TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient quantities (up to 20 mM) to allow ...

cd03074
Location:262 → 381

PDI_b'_Calsequestrin_C; Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient ...

pfam01216
Location:37 → 386

Calsequestrin; Calsequestrin