Aqp9 aquaporin 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aqp9provided by RGD
Official Full Name: aquaporin 9provided by RGD
Primary source: RGD:68433
See related: Ensembl:ENSRNOG00000061883 AllianceGenome:RGD:68433
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables water channel activity. Involved in canalicular bile acid transport and water transport. Located in basolateral plasma membrane and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in kidney disease. Orthologous to human AQP9 (aquaporin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 685.9) and Testes (RPKM 41.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (80678027..80718273, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (71797231..71837485, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (77559621..77599781, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA MALAT1 promotes neuropathic pain progression through the miR1545p/AQP9 axis in CCI rat models.
Title: LncRNA MALAT1 promotes neuropathic pain progression through the miR‑154‑5p/AQP9 axis in CCI rat models.
The maternal low-protein diet decreased AQP9 and VEGFr-2 expression, decreased epididymal microvascularity and altered the morphometric features of the epididymal epithelium.
Title: Maternal Protein Restriction Modulates Angiogenesis and AQP9 Expression Leading to a Delay in Postnatal Epididymal Development in Rat.
the combination of AQP9 gene knock-down and U0126 showed no further effect. Silencing AQP9 gene can inhibit the activation of ERK1/2 signaling pathway, attenuate the inflammatory response in rats with MI, inhibit apoptosis of myocardial cells, and improve cardiac function
Title: Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway.
that the overexpression of miR-212 inhibited AQP9 by activating the PI3K/Akt signaling pathway, thus decreasing cardiomyocytes apoptosis, promoting vascular regeneration and alleviating ventricular remodeling
Title: microRNA-212-induced protection of the heart against myocardial infarction occurs via the interplay between AQP9 and PI3K/Akt signaling pathway.
Downregulation of aquaporin 9 exacerbates beta-amyloid-induced neurotoxicity in Alzheimer's disease models in vitro and in vivo.
Title: Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer's Disease Models In vitro and In vivo.
The upregulation of AQP9 could be involved in gluconeogenesis and co-regulated by the JNK and p38 MAPK pathway in both Types 1 and 2 DM.
Title: Similar Aquaporin9 and MAPK Expression Profiles in the Liver of Types 1 and 2 Diabetes Mellitus.
AQP9 expression is increased slowly and reached a peak on day 14 in optic nerve after crushing.
Title: Changes in expression of aquaporin-4 and aquaporin-9 in optic nerve after crushing in rats.
dynamic changes in AQP9 expression, mediated in part via the p38 MAPK signal transduction pathway, may contribute to the development of cerebral oedema after brain ischaemia.
Title: Phosphorylation of p38 MAPK mediates aquaporin 9 expression in rat brains during permanent focal cerebral ischaemia.
we suggest that AQP9 is involved in viral tropism and pathogenesis of Herpes simplex encephalitis
Title: The anterior commissure is a pathway for contralateral spread of herpes simplex virus type 1 after olfactory tract infection.
Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator.
Title: Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator.

Submit: New GeneRIF Correction See all GeneRIFs (41)

General gene information

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Markers

RH141275 (e-PCR)
- UniSTS:223271

Aqp9 (e-PCR), detects polymorphism
- UniSTS:186498

Aqp9 (e-PCR), detects polymorphism
- UniSTS:209570

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol channel activity	ISO Inferred from Sequence Orthology more info
enables glycerol channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyol transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables purine nucleobase transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine nucleobase transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urea channel activity	ISO Inferred from Sequence Orthology more info
enables urea channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables urea transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urea transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in canalicular bile acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glycerol transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in polyol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleobase transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine nucleobase transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine-containing compound transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	TAS Traceable Author Statement more info	PubMed
involved_in response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urea transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in urea transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IDA Inferred from Direct Assay more info	PubMed
involved_in water transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aquaporin-9

Names: AQP-9; aquaglyceroporin-9; neutral solute channel aquaporin 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022960.2 → NP_075249.1 aquaporin-9

See identical proteins and their annotated locations for NP_075249.1

Status: PROVISIONAL

Source sequence(s)

BC085731

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7, A6KER9

Related

ENSRNOP00000069377.1, ENSRNOT00000087980.2

Conserved Domains (1) summary

cl00200
Location:4 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

80678027..80718273 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082097.2 → XP_038938025.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7, A6KER9

Conserved Domains (1) summary

cl00200
Location:4 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_006243362.3 → XP_006243424.1 aquaporin-9 isoform X1

See identical proteins and their annotated locations for XP_006243424.1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7, A6KER9

Conserved Domains (1) summary

cl00200
Location:4 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_063266084.1 → XP_063122154.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7
XM_039082095.2 → XP_038938023.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7, A6KER9

Conserved Domains (1) summary

cl00200
Location:4 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_039082099.2 → XP_038938027.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7, A6KER9

Conserved Domains (1) summary

cl00200
Location:4 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_039082096.2 → XP_038938024.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7, A6KER9

Conserved Domains (1) summary

cl00200
Location:4 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_063266082.1 → XP_063122152.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7
XM_039082100.2 → XP_038938028.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7, A6KER9

Conserved Domains (1) summary

cl00200
Location:4 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
XM_063266083.1 → XP_063122153.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7
XM_063266086.1 → XP_063122156.1 aquaporin-9 isoform X2
XM_063266081.1 → XP_063122151.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7
XM_063266085.1 → XP_063122155.1 aquaporin-9 isoform X1

UniProtKB/Swiss-Prot

O88815, P56627

UniProtKB/TrEMBL

A6KER7