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    P2ry14 purinergic receptor P2Y14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171108, updated on 6-Jun-2024

    Summary

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    Official Symbol
    P2ry14provided by RGD
    Official Full Name
    purinergic receptor P2Y14provided by RGD
    Primary source
    RGD:70912
    See related
    Ensembl:ENSRNOG00000013872 AllianceGenome:RGD:70912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr105
    Summary
    Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Involved in immune response. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human P2RY14 (purinergic receptor P2Y14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 48.6), Spleen (RPKM 23.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See P2ry14 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145522598..145563074, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143372697..143413213, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149331948..149379336, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene uncharacterized LOC120100831 Neighboring gene G protein-coupled receptor 171 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. P2Y(14) receptor is functionally expressed in satellite glial cells and mediates interleukin-1β and chemokine CCL2 secretion. Lin J, et al. J Cell Physiol, 2019 Nov. PMID 31032956
    2. Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells. Li F, et al. J Ethnopharmacol, 2016 Jun 5. PMID 26976766
    3. UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation. Gao ZG, et al. Biochem Pharmacol, 2010 Mar 15. PMID 19896471, Free PMC Article
    4. The P2Y14 receptor activity in glioma C6 cells. Krzemiński P, et al. Eur J Pharmacol, 2008 Oct 10. PMID 18638471
    5. Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s). Kinoshita M, et al. Cell Mol Neurobiol, 2013 Jan. PMID 22872320

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings directly proved the functional presence of P2Y14 receptor in satellite glial cells. It was also verified that P2Y14 receptor activation was involved in activating satellite glial cells
      Title: P2Y(14) receptor is functionally expressed in satellite glial cells and mediates interleukin-1β and chemokine CCL2 secretion.
    2. Geniposide exerted anti-inflammatory effects by interfering with the expression of P2Y14 receptor, which subsequently inhibits the downstream ERK1/2 signaling pathways and the release of the pro-inflammatory cytokines IL-8, MCP-1, IL-1beta.
      Title: Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells.
    3. When Gi-coupled signaling is removed from astrocyte P2Y14 receptors, the cells start to release TNF-alpha, boosting MMP-9 secretion.
      Title: Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s).
    4. Mast cells express an endogenous P2Y(14) receptor, which mediates G(i)-dependent degranulation and is therefore a potential novel therapeutic target for allergic conditions.
      Title: UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation.
    5. These results demonstrate a novel function of the P2Y14 receptor in the rodent stomach and an ability of UDP-glucose to delay gastric emptying without involving the P2Y14 receptor.
      Title: UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms.
    6. we demonstrated the presence and the activity of the P2Y14 receptor in glioma C6 cells
      Title: The P2Y14 receptor activity in glioma C6 cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC93098

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P2Y purinoceptor 14
    Names
    G protein-coupled receptor 105
    G protein-coupled receptor VTR 15-20
    P2Y14
    UDP-glucose receptor
    VTR 15-20
    purinergic receptor P2Y, G-protein coupled, 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133577.2 → NP_598261.2  P2Y purinoceptor 14

      Status: VALIDATED

      Source sequence(s)
      FM071543, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
      Related
      ENSRNOP00000088251.1, ENSRNOT00000090538.2
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 306
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      145522598..145563074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101620.2 → XP_038957548.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 306
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_039101618.2 → XP_038957546.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
      Related
      ENSRNOP00000073889.1
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 306
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_063281219.1 → XP_063137289.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4

    4. XM_039101621.2 → XP_038957549.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 306
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_017590600.3 → XP_017446089.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 306
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_017590599.3 → XP_017446088.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
      Related
      ENSRNOP00000093144.1
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 306
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_063281221.1 → XP_063137291.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4

    8. XM_039101622.2 → XP_038957550.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 306
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    9. XM_063281220.1 → XP_063137290.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      O35881
      UniProtKB/TrEMBL
      A0A0G2K2N8, A0A9K3Y832, Q5XIX4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35881.1 GenPept UniProtKB/Swiss-Prot:O35881

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