Mgll monoglyceride lipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mgllprovided by RGD
Official Full Name: monoglyceride lipaseprovided by RGD
Primary source: RGD:71039
See related: Ensembl:ENSRNOG00000014508 AllianceGenome:RGD:71039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MAGL
Summary: Enables acylglycerol lipase activity. Involved in monoacylglycerol catabolic process and positive regulation of vasoconstriction. Located in synapse. Orthologous to human MGLL (monoglyceride lipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 964.0), Testes (RPKM 606.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (122749436..122851440)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (121192186..121294187)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (120671436..120773458)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head.
Title: Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head.
4 weeks of post-weaning social isolation increased aggressive grooming of a novel same-sex conspecific in male and female rats. Treatment with the MAGL inhibitor MJN110 eliminated this increase in aggressive grooming in both males and females, without reducing non-aggressive social behavior. Activation of the medial prefrontal cortex was increased by social interaction but was blunted by MJN110 only in females.
Title: Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation.
MGL has an important role in insulin secretion
Title: Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets.
expression of MAGL is distributed in certain cell types and time-dependently expressed in skeletal muscles after trauma, suggesting that MAGL may be involved in inflammatory response, fibrogenesis and regeneration during skeletal muscle wound healing
Title: The distribution and time-dependent expression of MAGL during skeletal muscle wound healing in rats.
MAGL inhibitor JZL184 is able to inhibit the inflammatory response and interfere with contused muscle healing.
Title: The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.
results suggest that MAGL regulates phagocytosis, but not LPS-mediated cytokine induction in microglia
Title: Monoacylglycerol lipase promotes Fcγ receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines.
the current findings support the therapeutic potential of FAAH and monoacylglycerol lipase inhibitors as a novel pharmacotherapy for pain
Title: Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.
Data indicate that nerve growth factor (NGF) controls monoacylglycerol lipase (MGL) degradation in vitro and in vivo.
Title: Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons.
Pretreatment with MAGL inhibitor URB602 significantly reduces neonatal hypoxic-ischemic brain damage and improves functional outcome.
Title: Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats.
Maternal deprivation induced a significant decrease in MAGL immunoreactivity in the rat hippocampal CA3 and CA1 areas, more marked in males than in females.
Title: Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables acylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables acylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acylglycerol lipase activity	TAS Traceable Author Statement more info
enables hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in acylglycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in monoacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocannabinoid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	TAS Traceable Author Statement more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monoglyceride lipase

Names: MGL; monoacylglycerol lipase

NP_001385526.1

EC 3.1.1.23

NP_612511.1

EC 3.1.1.23

XP_063141749.1

EC 3.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398597.1 → NP_001385526.1 monoglyceride lipase isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IB48

Related

ENSRNOP00000070667.1, ENSRNOT00000077231.2

Conserved Domains (1) summary

cl21494
Location:38 → 312

Abhydrolase; alpha/beta hydrolases
NM_138502.3 → NP_612511.1 monoglyceride lipase isoform 2

See identical proteins and their annotated locations for NP_612511.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q32PZ2, Q8R431

UniProtKB/TrEMBL

A0A8I5ZPF3, A6IB49

Related

ENSRNOP00000030271.5, ENSRNOT00000029125.7

Conserved Domains (2) summary

pfam12146
Location:41 → 275

Hydrolase_4; Serine aminopeptidase, S33

cl21494
Location:22 → 296

Abhydrolase; alpha/beta hydrolases