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    Atp5mf ATP synthase membrane subunit f [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690441, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Atp5mfprovided by RGD
    Official Full Name
    ATP synthase membrane subunit fprovided by RGD
    Primary source
    RGD:1596067
    See related
    AllianceGenome:RGD:1596067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5j2
    Summary
    Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP metabolic process. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5MF (ATP synthase membrane subunit f). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 3586.6), Muscle (RPKM 2664.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (14535435..14542007)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (9421665..9428236)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (11191799..11198369)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene zinc finger protein 394 Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene pentatricopeptide repeat domain 1 Neighboring gene BUD31 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, et al. J Biol Chem, 2000 Oct 20. PMID 10887193
    2. Identification of two proteins associated with mammalian ATP synthase. Meyer B, et al. Mol Cell Proteomics, 2007 Oct. PMID 17575325
    3. A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies. Aggeler R, et al. J Biol Chem, 2002 Sep 13. PMID 12110673
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven mitochondrial ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit f, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
    NP_001258046.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271117.1 → NP_001258046.1  ATP synthase subunit f, mitochondrial

      See identical proteins and their annotated locations for NP_001258046.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      D3ZAF6
      UniProtKB/TrEMBL
      A0A8L2QG86
      Conserved Domains (1) summary
      pfam10206
      Location:8 → 84
      WRW; Mitochondrial F1F0-ATP synthase, subunit f

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      14535435..14542007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZAF6.1 GenPept UniProtKB/Swiss-Prot:D3ZAF6

    Gene LinkOut

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