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    Nav1 neuron navigator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685707, updated on 6-Jun-2024

    Summary

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    Symbol
    Nav1provided by RGD
    Full Name
    neuron navigator 1provided by RGD
    Primary source
    RGD:1590261
    See related
    Ensembl:ENSRNOG00000008425 AllianceGenome:RGD:1590261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in microtubule bundle formation and neuron migration. Predicted to be active in axon initial segment and microtubule cytoskeleton. Orthologous to human NAV1 (neuron navigator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 69.3), Heart (RPKM 57.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nav1 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49418755..49671117, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46866972..47119368, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52260474..52515016, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene shisa family member 4 Neighboring gene importin 9 Neighboring gene uncharacterized LOC134481562 Neighboring gene uncharacterized LOC120096254 Neighboring gene uncharacterized LOC102553722 Neighboring gene cysteine and glycine-rich protein 1 Neighboring gene ribosomal protein L11, pseudogene 12 Neighboring gene pleckstrin homology-like domain, family A, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain. Xu LJ, et al. Pain Physician, 2023 May. PMID 37192244
    2. Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration. Martínez-López MJ, et al. Mol Cell Neurosci, 2005 Apr. PMID 15797708
    3. TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays. van Beuningen SFB, et al. Neuron, 2015 Dec 16. PMID 26671463
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain.
      Title: Reduction of SIRT1-Mediated Epigenetic Upregulation of Nav1.7 Contributes to Oxaliplatin-Induced Neuropathic Pain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon initial segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuron navigator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427517.2 → NP_001414446.1  neuron navigator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      D4A5I4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      49418755..49671117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272611.1 → XP_063128681.1  neuron navigator 1 isoform X3

      UniProtKB/TrEMBL
      D4A5I4, F1M031

    2. XM_063272612.1 → XP_063128682.1  neuron navigator 1 isoform X4

      UniProtKB/TrEMBL
      D4A5I4

    3. XM_063272610.1 → XP_063128680.1  neuron navigator 1 isoform X2

      UniProtKB/TrEMBL
      D4A5I4, F1LYK3

    4. XM_063272608.1 → XP_063128678.1  neuron navigator 1 isoform X1

      UniProtKB/TrEMBL
      D4A5I4

    5. XM_063272613.1 → XP_063128683.1  neuron navigator 1 isoform X5

      UniProtKB/TrEMBL
      A6ICF5

    6. XM_063272609.1 → XP_063128679.1  neuron navigator 1 isoform X1

      UniProtKB/TrEMBL
      D4A5I4

    7. XM_063272615.1 → XP_063128685.1  neuron navigator 1 isoform X7

      UniProtKB/TrEMBL
      A6ICF5

    8. XM_063272614.1 → XP_063128684.1  neuron navigator 1 isoform X6

      UniProtKB/TrEMBL
      A6ICF5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.