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    Cpne2 copine 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498972, updated on 13-Apr-2024

    Summary

    Official Symbol
    Cpne2provided by RGD
    Official Full Name
    copine 2provided by RGD
    Primary source
    RGD:1586036
    See related
    Ensembl:ENSRNOG00000043286 AllianceGenome:RGD:1586036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Orthologous to human CPNE2 (copine 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 66.0), Lung (RPKM 50.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    19p13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10440245..10477783, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10434277..10472146, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10860963..10898970, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene uncharacterized LOC134483687 Neighboring gene uncharacterized LOC134483689 Neighboring gene NLR family, CARD domain containing 5 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC134483688

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    NOT located_in clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256466.2NP_001243395.1  copine-2

      See identical proteins and their annotated locations for NP_001243395.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2K0K1, F1M1L9, H1UBM7
      Related
      ENSRNOP00000063507.4, ENSRNOT00000063791.4
      Conserved Domains (3) summary
      cd04047
      Location:155267
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:24141
      C2A_Copine; C2 domain first repeat in Copine
      pfam07002
      Location:326542
      Copine

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      10440245..10477783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_010060019.1 RNA Sequence