Cryl1 crystallin, lambda 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cryl1provided by RGD
Official Full Name: crystallin, lambda 1provided by RGD
Primary source: RGD:631427
See related: Ensembl:ENSRNOG00000008989 AllianceGenome:RGD:631427
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable L-gulonate 3-dehydrogenase activity; NAD+ binding activity; and protein homodimerization activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytosol. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 495.0), Heart (RPKM 55.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (35542628..35661563, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (31427011..31545997, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (37543727..37663586, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-gulonate 3-dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-gulonate 3-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables L-gulonate 3-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables L-gulonate 3-dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucuronate catabolic process to xylulose 5-phosphate	IEA Inferred from Electronic Annotation more info
involved_in glucuronate catabolic process to xylulose 5-phosphate	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lambda-crystallin homolog

Names: L-gulonate 3-dehydrogenase; crystallin, lamda 1; gul3DH

NP_786933.1

EC 1.1.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175757.3 → NP_786933.1 lambda-crystallin homolog

See identical proteins and their annotated locations for NP_786933.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q811X6

UniProtKB/TrEMBL

A0A8I5ZZK9

Related

ENSRNOP00000012093.2, ENSRNOT00000012093.4

Conserved Domains (3) summary

PRK06129
Location:9 → 314

PRK06129; 3-hydroxyacyl-CoA dehydrogenase; Validated

pfam00725
Location:192 → 261

3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

pfam02737
Location:9 → 186

3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain