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    Mcm10 minichromosome maintenance 10 replication initiation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307126, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mcm10provided by RGD
    Official Full Name
    minichromosome maintenance 10 replication initiation factorprovided by RGD
    Primary source
    RGD:1311330
    See related
    Ensembl:ENSRNOG00000017981 AllianceGenome:RGD:1311330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; enzyme binding activity; and identical protein binding activity. Predicted to be involved in DNA replication initiation and cellular response to DNA damage stimulus. Predicted to act upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of replication fork protection complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 73.3), Spleen (RPKM 41.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcm10 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (78172049..78197644)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (73263788..73288346)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (77224218..77245486)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348590 Neighboring gene optineurin Neighboring gene uncharacterized LOC134482742 Neighboring gene upper zone of growth plate and cartilage matrix associated Neighboring gene phytanoyl-CoA 2-hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality. Lim HJ, et al. Biochim Biophys Acta, 2011 Oct. PMID 21693137
    2. Hexameric ring structure of human MCM10 DNA replication factor. Okorokov AL, et al. EMBO Rep, 2007 Oct. PMID 17823614, Free PMC Article
    3. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Miotto B, et al. Cell Rep, 2014 Apr 24. PMID 24726359
    4. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Izumi M, et al. Nucleic Acids Res, 2000 Dec 1. PMID 11095689, Free PMC Article
    5. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein MCM10 homolog
    Names
    minichromosome maintenance complex component 10
    minichromosome maintenance deficient 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107366.1 → NP_001100836.1  protein MCM10 homolog

      See identical proteins and their annotated locations for NP_001100836.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473990
      UniProtKB/TrEMBL
      A6JLZ2, D3Z8C4
      Related
      ENSRNOP00000024178.5, ENSRNOT00000024178.7
      Conserved Domains (2) summary
      pfam09329
      Location:402 → 447
      zf-primase; Primase zinc finger
      pfam09332
      Location:545 → 887
      Mcm10; Mcm10 replication factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      78172049..78197644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095781.2 → XP_038951709.1  protein MCM10 homolog isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:87 → 283
      PHA03247; large tegument protein UL36; Provisional
      pfam09329
      Location:346 → 391
      zf-primase; Primase zinc finger
      pfam09332
      Location:492 → 831
      Mcm10; Mcm10 replication factor

    2. XM_063276495.1 → XP_063132565.1  protein MCM10 homolog isoform X2

    3. XM_039095782.2 → XP_038951710.1  protein MCM10 homolog isoform X3

      Conserved Domains (2) summary
      pfam09329
      Location:46 → 91
      zf-primase; Primase zinc finger
      pfam09332
      Location:192 → 531
      Mcm10; Mcm10 replication factor
    Nucleotide Protein Strain
    Heading Accession and Version

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